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Disturbed left and ...
Disturbed left and right ventricular kinetic energy in patients with repaired tetralogy of Fallot : pathophysiological insights using 4D-flow MRI
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- Sjöberg, Pia (författare)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Bidhult, Sebastian (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Bock, Jelena (författare)
- Skåne University Hospital,Lund University
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- Heiberg, Einar (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Matematikcentrum,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Centre for Mathematical Sciences,Faculty of Engineering, LTH,Skåne University Hospital
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- Arheden, Håkan (författare)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Gustafsson, Ronny (författare)
- Lund University,Lunds universitet,NPWT teknologin,Forskargrupper vid Lunds universitet,NPWT technology,Lund University Research Groups,Skåne University Hospital
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- Nozohoor, Shahab (författare)
- Lund University,Lunds universitet,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Skåne University Hospital
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- Carlsson, Marcus (författare)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2018-04-17
- 2018
- Engelska.
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 28:10, s. 4066-4076
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Indications for pulmonary valve replacement (PVR) in patients with pulmonary regurgitation (PR) after repaired tetralogy of Fallot (rToF) are debated. We aimed to compare right (RV) and left ventricular (LV) kinetic energy (KE) measured by 4D-flow magnetic resonance imaging (MRI) in patients to controls, to further understand the pathophysiological effects of PR. Methods: Fifteen patients with rToF with PR > 20% and 14 controls underwent MRI. Ventricular volumes and KE were quantified from cine MRI and 4D-flow, respectively. Lagrangian coherent structures were used to discriminate KE in the PR. Restrictive RV physiology was defined as end-diastolic forward flow. Results: LV systolic peak KE was lower in rToF, 2.8 ± 1.1 mJ, compared to healthy volunteers, 4.8 ± 1.1 mJ, p < 0.0001. RV diastolic peak KE was higher in rToF (7.7 ± 4.3 mJ vs 3.1 ± 1.3 mJ, p = 0.0001) and the difference most pronounced in patients with non-restrictive RV physiology. KE was primarily located in the PR volume at the time of diastolic peak KE, 64 ± 17%. Conclusion: This is the first study showing disturbed KE in patients with rToF and PR, in both the RV and LV. The role of KE as a potential early marker of ventricular dysfunction to guide intervention needs to be addressed in future studies. Key Points: • Kinetic energy (KE) reflects ventricular performance• KE is a potential marker of ventricular dysfunction in Fallot patients• KE is disturbed in both ventricles in patients with tetralogy of Fallot• KE contributes to the understanding of the pathophysiology of pulmonary regurgitation• Lagrangian coherent structures enable differentiation of ventricular inflows
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart defects, Congenital
- Heart failure
- Magnetic resonance imaging, Cine
- Pulmonary valve
- Tetralogy of Fallot
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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