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Long-term follow-up...
Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy
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- Ljungman, P. (författare)
- Karolinska Institutet
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Locasciulli, A. (författare)
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de Soria, V. G. (författare)
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visa fler...
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- Békássy, Albert (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Brinch, L. (författare)
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Espigado, I. (författare)
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Ferrant, A. (författare)
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Franklin, I. M. (författare)
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O'Riordan, J. (författare)
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Rovira, M. (författare)
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Shaw, P. (författare)
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Einsele, H. (författare)
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(creator_code:org_t)
- 2011-12-12
- 2012
- Engelska.
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 1476-5365 .- 0268-3369. ; 47:9, s. 1217-1221
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This prospective study was initiated in 1993 with the aim to study late effects and responses to antiviral therapy in a cohort of hepatitis C virus (HCV)-infected patients. A total of 195 patients were included from 12 centers. In all, 134 patients had undergone allogeneic and 61 autologous hematopoietic SCT (HSCT). The median follow-up from HSCT is currently 16.8 years and the maximum 27.2 years. Overall 33 of 195 patients have died of which 6 died from liver complications. The survival probability was 81.6% and the cumulative incidence for death in liver complications was 6.1% at 20 years after HSCT. The cumulative incidence of severe liver complications (death from liver failure, cirrhosis and liver transplantation) was 11.7% at 20 years after HSCT. In all, 85 patients have been treated with IFN; 42 in combination with ribavirin. The sustained response rate was 40%. The rates of severe side effects were comparable to other patient populations and no patient developed significant exacerbations of GVHD. Patients receiving antiviral therapy had a trend toward a decreased risk of severe liver complications (odds ratio=0.33; P=0.058). HCV infection is associated with morbidity and mortality in long-term survivors after HSCT. Antiviral therapy can be given safely and might reduce the risk for severe complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Hepatitis C virus
- antiviral therapy
- late effects
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Ljungman, P.
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Locasciulli, A.
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de Soria, V. G.
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Békássy, Albert
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Brinch, L.
-
Espigado, I.
-
visa fler...
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Ferrant, A.
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Franklin, I. M.
-
O'Riordan, J.
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Rovira, M.
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Shaw, P.
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Einsele, H.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Bone Marrow Tran ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet