Optic nerve hypoplasia: Risk factors and epidemiology.

• OBJECTIVES: To study the epidemiology of optic nerve hypoplasia. DESIGN AND METHODS: Children with optic nerve hypoplasia and visual impairment were identified through the Swedish Register of Visually Impaired Children. Pre- and perinatal characteristics were obtained from the Medical Birth Registry and by scrutinizing pregnancy and delivery records. Clinical characteristics of children with optic nerve hypoplasia are described. The following risk factors were studied: maternal age, parity, maternal smoking, gestational duration, birth weight, delivery method, Apgar score, maternal disease during pregnancy, drugs used in early pregnancy. RESULTS: Young maternal age, first parity, maternal smoking, preterm birth and factors associated with preterm birth were risk factors for optic nerve hypoplasia. There was an indicated association with the use of fertility drugs and antidepressant drugs. CONCLUSIONS: Optic nerve hypoplasia is apparently associated not only with other anomolies, notably of the central nervous system, but also with signs of general disturbance in fetal development.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

Nyckelord

Infant

Human

Female

Eye Abnormalities : epidemiology

Preschool

Child

Adolescence

Adult

Premature

Maternal Age

Male

Optic Nerve : abnormalities

Registries : statistics & numerical data

Risk Factors

Smoking : epidemiology

Non-U.S. Gov't

Support

Sweden : epidemiology

Vision Disorders : epidemiology

Visually Impaired Persons : statistics & numerical data

Newborn

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)