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Array-CGH reveals h...
Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding
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Kuchinskaya, Ekaterina (author)
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- Heyman, Mats (author)
- Karolinska Institutet
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- Nordgren, Ann (author)
- Karolinska Institutet
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- Schoumans, Jacqueline (author)
- Karolinska Institutet
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Söderhäll, Stefan (author)
- Karolinska Institutet
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- Grander, Dan (author)
- Karolinska Institutet
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Nordenskjöld, Magnus (author)
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- Blennow, Elisabeth (author)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 140:5, s. 572-577
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Abstract
Subject headings
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- A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- tiling-resolution array-comparative genomic hybridization
- childhood acute lymphoblastic leukaemia
- normal karyotype
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kuchinskaya, Eka ...
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Heyman, Mats
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Nordgren, Ann
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Schoumans, Jacqu ...
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Staaf, Johan
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Borg, Åke
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show more...
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Söderhäll, Stefa ...
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Grander, Dan
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Nordenskjöld, Ma ...
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Blennow, Elisabe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Lund University
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Karolinska Institutet