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Smoking and the ris...
Smoking and the risk of LADA : Results from a Swedish population-based case-control study
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- Rasouli, Bahareh (författare)
- Karolinska Institutet
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- Andersson, Tomas (författare)
- Karolinska Institutet
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Uppsala University,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
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- Grill, Valdemar (författare)
- St. Olav’s University Hospital,Norwegian Univ Sci & Technol, NTNU Inst Canc Res & Mol Med, N-7034 Trondheim, Norway.;Univ Trondheim Hosp, Dept Endocrinol, Trondheim, Norway.
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Lund Univ, Dept Clin Sci Malmo, Clin Res Ctr, Malmo, Sweden.
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- Martinell, Mats (författare)
- Uppsala universitet,Uppsala University,Allmänmedicin och preventivmedicin
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- Storm, Petter (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Lund Univ, Dept Clin Sci Malmo, Clin Res Ctr, Malmo, Sweden.
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- Tuomi, Tiinamaija (författare)
- Helsinki University Central Hospital,Helsinki Univ Hosp, Div Endocrinol, Helsinki, Finland.;Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland.;Univ Helsinki, Res Program Diabet & Obes, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.
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- Carlsson, Sofia (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-04-17
- 2016
- Engelska 7 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 39:5, s. 794-800
- Relaterad länk:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Smoking is an established risk factor for type 2 diabetes. In contrast, it has been proposed that smoking may reduce the risk of latent autoimmune diabetes in adults (LADA), but studies are scarce. We aimed to study the impact of smoking on LADA and type 2 diabetes risks. RESEARCH DESIGN AND METHODS: We used data from a Swedish case-control study including incident case patients with LADA (GAD antibody [GADA] positive, n = 377) and type 2 diabetes (GADA negative, n = 1,188) and control subjects randomly selected from the population (n = 1,472). We calculated odds ratios (ORs) with 95% CIs by logistic regression, adjusted for age, sex, BMI, family history of diabetes, and alcohol consumption. RESULTS: There was no indication of reduced risk of LADA in smokers; instead, heavy smoking was associated with an increased risk of LADA (OR 1.37, 95% CI 1.02-1.84). Heavy smokers had higher levels of HOMA of insulin resistance (9.89 vs. 4.38, P = 0.0479) and HOMA of β-cell function (55.7 vs. 42.5, P = 0.0204), but lower levels of GADA (75 vs. 250, P = 0.0445), compared with never smokers. Smokers also displayedanincreased risk oftype2 diabetes (OR in eversmokers 1.53, 95% CI 1.25-1.88). CONCLUSIONS: In this large population of LADA patients, we did not observe a protective effect of smoking on autoimmunity and the risk of LADA. A protective effect could possibly be masked by a smoking-induced aggravation of insulin resistance, akin to the diabetogenic effect seen in individuals with type 2 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ANDIS
- diabetes
- diabetics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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