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Sökning: id:"swepub:oai:lup.lub.lu.se:162611b1-df76-496e-a9fb-df79e6cbc8b2" > Circulating dipepti...

Circulating dipeptidyl peptidase 3 on intensive care unit admission is a predictor of organ dysfunction and mortality

Frigyesi, Attila (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Intensivvårdsepidemiologi,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Intensive Care Epidemiology,Skåne University Hospital
Lengquist, Maria (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
Spångfors, Martin (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Centrum för hjärtstopp,Klinisk forskning inom anestesi och intensivvårdsmedicin,SWECRIT,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Center for cardiac arrest,Clinical Research in Anaesthesia and Intensive Care Medicine,Central Hospital Kristianstad
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Annborn, Martin (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Centrum för hjärtstopp,Klinisk forskning inom anestesi och intensivvårdsmedicin,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Center for cardiac arrest,Clinical Research in Anaesthesia and Intensive Care Medicine,Helsingborg Hospital
Cronberg, Tobias (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Centrum för hjärtstopp,Brain Injury After Cardiac Arrest,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Center for cardiac arrest,Skåne University Hospital
Nielsen, Niklas (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Centrum för hjärtstopp,Klinisk forskning inom anestesi och intensivvårdsmedicin,SEBRA Sepsis and Bacterial Resistance Alliance,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Center for cardiac arrest,Clinical Research in Anaesthesia and Intensive Care Medicine,Helsingborg Hospital
Levin, Helena (författare)
Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Anestesiologi och intensivvård,Centrum för hjärtstopp,Research Network on Education and Sustainable Deelopment-lup-obsolete,Lund University Research Groups,Anaesthesiology and Intensive Care Medicine,Center for cardiac arrest,Skåne University Hospital
Friberg, Hans (författare)
Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Centrum för hjärtstopp,SWECRIT,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Center for cardiac arrest,Skåne University Hospital
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 (creator_code:org_t)
2021-08-24
2021
Engelska.
Ingår i: Journal of Intensive Care. - : Springer Science and Business Media LLC. - 2052-0492. ; 9:1
Relaterad länk:
http://dx.doi.org/10... (free)
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https://jintensiveca...
https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: Our aim was to investigate the prognostic potential of circulating dipeptidyl peptidase 3 (cDPP3) to predict mortality and development of organ dysfunction in a mixed intensive care unit (ICU) population, and for this reason, we analysed prospectively collected admission blood samples from adult ICU patients at four Swedish hospitals. Blood samples were stored in a biobank for later batch analysis. The association of cDPP3 levels with 30-day mortality and Sequential Organ Failure Assessment (SOFA) scores on day two was investigated before and after adjustment for the simplified acute physiology score III (SAPS-3), using multivariable (ordinal) logistic regression. The predictive power of cDPP3 was assessed using the area under the receiver operating characteristic curve (AUROC).RESULTS: Of 1978 included consecutive patients in 1 year (2016), 632 fulfilled the sepsis 3-criteria, 190 were admitted after cardiac arrest, and 157 because of trauma. Admission cDPP3 was independently (of SAPS-3) associated with 30-day mortality with odds ratios of 1.45 (95% confidence interval (CI) 1.28-1.64) in the entire ICU population, 1.30 (95% CI 1.08-1.57) in the sepsis subgroup and 2.28 (95% CI 1.50-3.62) in cardiac arrest. For trauma, there was no clear association. Circulating DPP3 alone was a moderate predictor of 30-day mortality with AUROCs of 0.68, 0.62, and 0.72 in the entire group, the sepsis subgroup, and the cardiac arrest subgroup, respectively. By adding cDPP3 to SAPS-3, AUROC improved for the entire group, the sepsis subgroup, and the cardiac arrest subgroup (p = 0.023).CONCLUSION: Circulating DPP3 on admission is a SAPS-3 independent prognostic factor of day-two organ dysfunction and 30-day mortality in a mixed ICU population and needs further evaluation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

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