id:"swepub:oai:lup.lub.lu.se:164132e2-4bdd-4417-b508-3f601bd3a385"
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A new antitumour treatment combining radiation and electric pulses
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- Engström, P E (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Persson, B R (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Rausing laboratory of Lund - Tumor section,Lund University Research Groups,Skåne University Hospital
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- Brun, A (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- (creator_code:org_t)
- 2001
- 2001
- Engelska 7 s.
- Ingår i: Anticancer research. - 0250-7005. ; 21:3B, s. 15-1809
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- AIM: To investigate the antitumour effect of radiation in combination with electropermeabilization on subcutaneous rat glioma tumours.MATERIALS AND METHODS: Sub-optimal radiation treatment was administered separately or in combination with electric pulses of high voltage to subcutaneous rat brain tumours. The treatment was repeated on four consecutive days and evaluated by TGD and microscopical examination. The tumours were stained for Factor VlII/von Willebrand Factor to investigate the effects on the tumour vasculature.RESULTS: Radiation and electric pulses applied concomitantly resulted in a cure rate of 67% (tumour free >80 days after treatment). Radiation-treated animals showed progressive disease. Histological and immunohistochemical examination of electric impulse-treated tumours showed instant and severe deteriorating effects on tumour vasculature.CONCLUSION: A distinct antitumour effect of the combined treatment of electric pulses and radiation treatment was observed. We believe that the tumouricidal effect arises from destruction of the tumour vasculature but also from DNA related damage from reactive oxygen formed by the electric pulses and the radiation treatment.
Nyckelord
- Animals
- Brain Neoplasms
- Combined Modality Therapy
- Electric Stimulation Therapy
- Electricity
- Factor VIII
- Glioma
- Immunohistochemistry
- Male
- Neoplasms
- Rats
- Rats, Inbred F344
- Time Factors
- Journal Article
- Research Support, Non-U.S. Gov't
Publikations- och innehållstyp
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- Engström, P E
- Persson, B R
- Brun, A
- Salford, L G
- Artiklar i publikationen
- Anticancer resea ...
- Av lärosätet
- Lunds universitet
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