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Pharmacology of the...
Pharmacology of the Bladder and Emerging Treatments
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- Andersson, Karl Erik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Wake Forest University
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(creator_code:org_t)
- 5th
- 2023
- 2023
- Engelska 20 s.
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Ingår i: Textbook of Female Urology and Urogynecology : Clinical Perspectives - Clinical Perspectives. - 9781000631210 - 9780367700140 ; , s. 218-237
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The nervous mechanisms for bladder emptying and urine storage involve a complex pattern of afferent and efferent signaling in parasympathetic, sympathetic, and somatic nerves. During voiding, contraction of the detrusor muscle is preceded by a relaxation of the outlet region, thereby facilitating the bladder emptying. Kim et al. found that 14 of 31 patients with overactive bladder (OAB) and nocturia, refractory to antimuscarinic treatment, improved with oral gabapentin. Ansari et al. treated children with refractory OAB symptoms with gabapentin as an add-on and found the drug to give modest positive results. The NK1-receptor antagonist, netupitant, decreased the frequency of reflex bladder contractions without altering their amplitude, suggesting that this drug targets the afferent limb of the micturition reflex circuit and therefore may be useful clinically in treating bladder overactivity symptoms. Possible peripheral targets for pharmacological intervention may be the efferent neurotransmission, the smooth muscle itself, including ion channels and intracellular second messenger systems, and the afferent neurotransmission.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publikations- och innehållstyp
- kap (ämneskategori)
- ref (ämneskategori)
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