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Second-generation c...
Second-generation colon capsule endoscopy compared with colonoscopy
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Spada, Cristiano (författare)
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Hassan, Cesare (författare)
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Munoz-Navas, Miguel (författare)
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Neuhaus, Horst (författare)
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Deviere, Jacques (författare)
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Fockens, Paul (författare)
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Coron, Emmanuel (författare)
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Gay, Gerard (författare)
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- Toth, Ervin (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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Riccioni, Maria Elena (författare)
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Carretero, Cristina (författare)
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Charton, Jean P. (författare)
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Van Gossum, Andre (författare)
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Wientjes, Carolien A. (författare)
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Sacher-Huvelin, Sylvie (författare)
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Delvaux, Michel (författare)
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- Nemeth, Artur (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Petruzziello, Lucio (författare)
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Prieto de Frias, Cesar (författare)
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Mayershofer, Rupert (författare)
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Aminejab, Leila (författare)
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Dekker, Evelien (författare)
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Gahniche, Jean-Paul (författare)
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Frederic, Muriel (författare)
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Johansson, Gabriele Wurm (författare)
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Cesaro, Paola (författare)
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Costamagna, Guido (författare)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: Gastrointestinal Endoscopy. - : Elsevier BV. - 1097-6779 .- 0016-5107. ; 74:3, s. 581-589
- Relaterad länk:
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http://dx.doi.org/10...
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https://dadun.unav.e...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. Objective: To assess the feasibility, accuracy, and safety of CCE-2 in a head-to-head comparison with colonoscopy. Design and Setting: Prospective, multicenter trial including 8 European sites. Patients: This study involved 117 patients (mean age 60 years). Data from 109 patients were analyzed. Intervention: CCE-2 was prospectively compared with conventional colonoscopy as the criterion standard for the detection of colorectal polyps that are >= 6 mm or masses in a cohort of patients at average or increased risk of colorectal neoplasia. Colonoscopy was independently performed within 10 hours after capsule ingestion or on the next day. Main Outcome Measurements: CCE-2 sensitivity and specificity for detecting patients with polyps >= 6 mm and >= 10 mm were assessed. Capsule-positive but colonoscopy-negative cases were counted as false positive. Capsule excretion rate, level of bowel preparation, and rate of adverse events also were assessed. Results: Per-patient CCE-2 sensitivity for polyps >= 6 mm and >= 10 mm was 84% and 88%, with specificities of 64% and 95%, respectively. All 3 invasive carcinomas were detected by CCE-2. The capsule excretion rate was 88% within 10 hours. Overall colon cleanliness for CCE-2 was adequate in 81% of patients. Limitations: Not unblinding the CCE-2 results at colonoscopy; heterogenous patient population; nonconsecutive patients. Conclusion: In this European, multicenter study, CCE-2 appeared to have a high sensitivity for the detection of clinically relevant polypoicl lesions, and it might be considered an adequate tool for colorectal imaging. (Gastrointest Enclose 201174:581-9.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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Spada, Cristiano
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Hassan, Cesare
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Munoz-Navas, Mig ...
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Neuhaus, Horst
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Deviere, Jacques
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Fockens, Paul
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visa fler...
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Coron, Emmanuel
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Gay, Gerard
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Toth, Ervin
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Riccioni, Maria ...
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Carretero, Crist ...
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Charton, Jean P.
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Van Gossum, Andr ...
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Wientjes, Caroli ...
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Sacher-Huvelin, ...
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Delvaux, Michel
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Nemeth, Artur
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Petruzziello, Lu ...
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Prieto de Frias, ...
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Mayershofer, Rup ...
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Aminejab, Leila
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Dekker, Evelien
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Gahniche, Jean-P ...
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Frederic, Muriel
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Johansson, Gabri ...
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Cesaro, Paola
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Costamagna, Guid ...
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