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Array-based genomic...
Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
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- Gunnarsson, Rebeqa (författare)
- Uppsala universitet,Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematologi och immunologi
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- Mansouri, Larry (författare)
- Uppsala universitet,Hematologi och immunologi
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- Isaksson, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer pharmacology and computational medicine
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- Göransson, Hanna (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer pharmacology and computational medicine
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- Cahill, Nicola (författare)
- Uppsala universitet,Hematologi och immunologi
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- Jansson, Mattias (författare)
- Uppsala universitet,Hematologi och immunologi
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- Rasmussen, Markus (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer pharmacology and computational medicine
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- Lundin, Jeanette (författare)
- Karolinska Institutet
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Norin, Stefan (författare)
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Buhl, Anne Mette (författare)
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- Smedby, Karin Ekstrom (författare)
- Karolinska Institutet
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Hjalgrim, Henrik (författare)
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- Karlsson, Karin (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Jurlander, Jesper (författare)
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Geisler, Christian (författare)
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- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Rosenquist Brandell, Richard (författare)
- Uppsala universitet,Hematologi och immunologi
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(creator_code:org_t)
- 2011-05-05
- 2011
- Engelska.
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 96:8, s. 1161-1169
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent aberrations in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], and copy-number neutral loss of heterozygosity. Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution. Design and Methods We screened samples from 369 patients with newly diagnosed chronic lymphocytic leukemia from a population-based cohort using 250K single nucleotide polymorphism-arrays. Clonal evolution was evaluated in 59 follow-up samples obtained after 5-9 years. Results At diagnosis, copy-number aberrations were identified in 90% of patients; 70% carried known recurrent alterations, including del(13q) (55%), trisomy 12 (10.5%), del(11q) (10%), and del(17p) (4%). Additional recurrent aberrations were detected on chromosomes 2 (1.9%), 4 (1.4%), 8 (1.6%) and 14 (1.6%). Thirteen patients (3.5%) displayed recurrent copy-number neutral loss of heterozygosity on 13q, of whom 11 had concurrent homozygous del(13q). Genomic complexity and large 13q deletions correlated with inferior outcome, while the former was linked to poor-prognostic aberrations. In the follow-up study, clonal evolution developed in 8/24 (33%) patients with unmutated IGHV, and in 4/25 (16%) IGHV-mutated and treated patients. In contrast, untreated patients with mutated IGHV (n=10) did not acquire additional aberrations. The most common secondary event, del(13q), was detected in 6/12 (50%) of all patients with acquired alterations. Interestingly, aberrations on, for example, chromosome 6q, 8p, 9p and 10q developed exclusively in patients with unmutated IGHV. Conclusions Whole-genome screening revealed a high frequency of genomic aberrations in newly diagnosed chronic lymphocytic leukemia. Clonal evolution was associated with other markers of aggressive disease and commonly included the known recurrent aberrations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- chronic lymphocytic leukemia
- SNP-array
- genomic aberrations
- CNN-LOH
- clonal evolution
- chronic lymphocytic leukemia
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gunnarsson, Rebe ...
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Mansouri, Larry
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Isaksson, Anders
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Göransson, Hanna
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Cahill, Nicola
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Jansson, Mattias
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visa fler...
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Rasmussen, Marku ...
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Lundin, Jeanette
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Norin, Stefan
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Buhl, Anne Mette
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Smedby, Karin Ek ...
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Hjalgrim, Henrik
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Karlsson, Karin
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Jurlander, Jespe ...
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Geisler, Christi ...
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Juliusson, Gunna ...
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Rosenquist Brand ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Haematologica
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet