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Autophagy-mediated ...
Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
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- López, Aida Rodríguez (författare)
- Danish Cancer Institute
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- Jørgensen, Maria H. (författare)
- Danish Cancer Institute
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- Havelund, Jesper F. (författare)
- University of Southern Denmark
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- Arendrup, Frederic S. (författare)
- University of Copenhagen
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- Kolapalli, Srinivasa Prasad (författare)
- Danish Cancer Institute
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- Nielsen, Thorbjørn M. (författare)
- Danish Cancer Institute,University of Copenhagen
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- Pais, Eva (författare)
- Danish Cancer Institute
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- Beese, Carsten Jörn (författare)
- Danish Cancer Institute
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- Abdul-Al, Ahmad (författare)
- Danish Cancer Institute
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- Vind, Anna Constance (författare)
- University of Copenhagen
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- Bartek, Jiri (författare)
- Karolinska Institutet,Danish Cancer Institute
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- Bekker-Jensen, Simon (författare)
- University of Copenhagen
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- Montes, Marta (författare)
- University of Copenhagen
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- Galanos, Panagiotis (författare)
- Danish Cancer Institute
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- Faergeman, Nils (författare)
- University of Southern Denmark
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- Happonen, Lotta (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Forskargrupper vid Lunds universitet,Strukturell infektionsmedicin,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Structural Infection Medicine (STRIME)
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- Frankel, Lisa B. (författare)
- Danish Cancer Institute
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Cell Reports. - 2211-1247. ; 42:11, s. 1-23
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling, which involves alterations in protein and organelle homeostasis through autophagy. Here, we show that ribosomes are selectively targeted for degradation by autophagy during OIS. By characterizing senescence-dependent alterations in the ribosomal interactome, we find that the deubiquitinase USP10 dissociates from the ribosome during the transition to OIS. This release of USP10 leads to an enhanced ribosome ubiquitination, particularly of small subunit proteins, including lysine 275 on RPS2. Both reinforcement of the USP10-ribosome interaction and mutation of RPS2 K275 abrogate ribosomal delivery to lysosomes without affecting bulk autophagy. We show that the selective recruitment of ubiquitinated ribosomes to autophagosomes is mediated by the p62 receptor. While ribophagy is not required for the establishment of senescence per se, it contributes to senescence-related metabolome alterations and facilitates the senescence-associated secretory phenotype.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- autophagy
- CP: Cell biology
- CP: Molecular biology
- oncogene-induced senescence
- ribosomes
- selective autophagy
- ubiquitin
- USP10
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
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López, Aida Rodr ...
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Jørgensen, Maria ...
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Havelund, Jesper ...
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Arendrup, Freder ...
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Kolapalli, Srini ...
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Nielsen, Thorbjø ...
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visa fler...
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Pais, Eva
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Beese, Carsten J ...
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Abdul-Al, Ahmad
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Vind, Anna Const ...
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Bartek, Jiri
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Bekker-Jensen, S ...
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Montes, Marta
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Galanos, Panagio ...
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Faergeman, Nils
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Happonen, Lotta
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Frankel, Lisa B.
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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Cell Reports
- Av lärosätet
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Lunds universitet
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Karolinska Institutet