Hypertension : pathophysiology and relevance to the cardiometabolic syndrome

• High blood pressure, or hypertension, is the leading single risk factor for the global burden of disease. Hypertension often coexists with several anthropometric and metabolic abnormalities, including abdominal obesity, dyslipidemia, and glucose intolerance—in combination referred to as metabolic (or cardiometabolic) syndrome. Indeed, hypertension occurs in a large proportion of those with metabolic syndrome; however, the interconnected relationship between the components of metabolic syndrome makes it challenging to determine the underlying causes and consequences. Metabolic disease is associated with arterial changes which favor the development and maintenance of hypertension, including endothelial dysfunction, arteriolar remodeling, and large artery stiffening. Thus it is evident that the vasculature plays a key role in perpetuating the relationship between hypertension and metabolic syndrome. Given that childhood health has a substantial influence on cardiometabolic health later in life, efforts should be targeted at the prevention of risk factor onset early in the life course, to stem the growing burden of both hypertension and metabolic disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Cardiovascular

endothelium

hypertension

metabolic syndrome

treatment

Publikations- och innehållstyp

kap (ämneskategori)

ref (ämneskategori)