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Remote ischemic per...
Remote ischemic perconditioning attenuates adverse cardiac remodeling and preserves left ventricular function in a rat model of reperfused myocardial infarction
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- Pilz, Patrick M. (författare)
- Medical University of Vienna
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- Hamza, Ouafa (författare)
- Medical University of Vienna
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- Gidlöf, Olof (författare)
- Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Gonçalves, Ines F. (författare)
- Medical University of Vienna
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- Tretter, Eva Verena (författare)
- Medical University of Vienna
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- Trojanek, Sandra (författare)
- Medical University of Vienna
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- Abraham, Dietmar (författare)
- Medical University of Vienna
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- Heber, Stefan (författare)
- Medical University of Vienna
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- Haller, Paul M. (författare)
- Medical University of Vienna
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- Podesser, Bruno K. (författare)
- Medical University of Vienna
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- Kiss, Attila (författare)
- Medical University of Vienna
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 285, s. 72-79
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims: Remote ischemic conditioning (RIC) is considered a potential clinical approach to reduce myocardial infarct size and ameliorate adverse post-infarct left ventricular (LV) remodeling, however the mechanisms are unknown. The aim was to clarify the impact of RIC on Neuregulin-1 (NRG-1)/ErbBs expression, inflammation and LV hemodynamic function. Methods and results: Male Sprague-Dawley rats were subjected to 30 min occlusion of the left coronary artery (LCA) followed by 2 weeks of reperfusion and separated into three groups: (1) sham operated (without LCA occlusion); (2) Myocardial ischemia/reperfusion (MIR) and (3) remote ischemic perconditioning group (MIR + RIPerc). Cardiac structural and functional changes were evaluated by echocardiography and on the isolated working heart system. The level of H3K4me3 at the NRG-1 promoter, and both plasma and LV tissue levels of NRG-1 were assessed. The expression of pro-inflammatory cytokines, ECM components and ErbB receptors were assessed by RT-qPCR. MIR resulted in a significant decrease in LV function and enlargement of LV chamber. This was accompanied with a decrease in the level of H3K4me3 at the NRG-1 promoter. Consequently NRG-1 protein levels were reduced in the infarcted myocardium. Subsequently, an upregulated influx of CD68+ macrophages, high expression of MMP-2 and -9 as well as an increase of IL-1β TLR-4, TNF-α TNC expression were observed. In contrast, RIPerc significantly decreased inflammation and improved LV function in association with the enhancement of NRG-1 levels and ErbB3 expression. Conclusions: These findings may reveal a novel anti-remodeling and anti-inflammatory effect of RIPerc, involving activation of NRG-1/ErbB3 signaling.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Epigenetic
- ErbB receptors
- Inflammation
- Myocardial infarction
- Neuregulin-1
- Remote ischemic perconditioning
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pilz, Patrick M.
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Hamza, Ouafa
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Gidlöf, Olof
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Gonçalves, Ines ...
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Tretter, Eva Ver ...
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Trojanek, Sandra
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visa fler...
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Abraham, Dietmar
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Heber, Stefan
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Haller, Paul M.
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Podesser, Bruno ...
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Kiss, Attila
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visa färre...
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och Kardiologi
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Lunds universitet