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Ambulatory oxygen f...
Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial) : A randomised controlled trial
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- Holland, Anne E. (författare)
- Monash University,National Health And Medical Research Council Centre Of Research Excellence In Pulmonary Fibrosis,Alfred Health,Institute for Breathing and Sleep (IBAS)
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- Corte, Tamera (författare)
- Royal Prince Alfred Hospital,University of Sydney,National Health And Medical Research Council Centre Of Research Excellence In Pulmonary Fibrosis
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- Chambers, Daniel C. (författare)
- National Health And Medical Research Council Centre Of Research Excellence In Pulmonary Fibrosis,The Prince Charles Hospital,University of Queensland
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- Palmer, Andrew J. (författare)
- National Health And Medical Research Council Centre Of Research Excellence In Pulmonary Fibrosis,University of Melbourne,University of Tasmania
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- Ekström, Magnus Per (författare)
- Lund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups
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- Glaspole, Ian (författare)
- Alfred Health,Monash University,National Health And Medical Research Council Centre Of Research Excellence In Pulmonary Fibrosis
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- Goh, Nicole S.L. (författare)
- University of Melbourne,Austin Health,Institute for Breathing and Sleep (IBAS)
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- Hepworth, Graham (författare)
- University of Melbourne
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- Khor, Yet H. (författare)
- Austin Health,Alfred Health,Institute for Breathing and Sleep (IBAS),University of Melbourne
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- Hoffman, Mariana (författare)
- Monash University
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- Vlahos, Ross (författare)
- RMIT University
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- Sköld, Magnus (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Dowman, Leona (författare)
- Institute for Breathing and Sleep (IBAS),Austin Health,Monash University
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- Troy, Lauren K. (författare)
- Royal Prince Alfred Hospital,University of Sydney
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- Prasad, Jyotika D. (författare)
- Alfred Health,Royal Melbourne Hospital
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- Walsh, James (författare)
- The Prince Charles Hospital
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- McDonald, Christine F. (författare)
- Institute for Breathing and Sleep (IBAS),University of Melbourne,Austin Health
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(creator_code:org_t)
- 2020-12-13
- 2020
- Engelska.
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 10:12
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http://dx.doi.org/10... (free)
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https://bmjopen.bmj....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction Interstitial lung diseases are characterised by scarring of lung tissue that leads to reduced transfer of oxygen into the blood, decreased exercise capacity and premature death. Ambulatory oxygen therapy may be used to treat exertional oxyhaemoglobin desaturation, but there is little evidence to support its efficacy and there is wide variation in clinical practice. This study aims to compare the clinical efficacy and cost-effectiveness of ambulatory oxygen versus ambulatory air in people with fibrotic interstitial lung disease and exertional desaturation. Methods and analysis A randomised, controlled trial with blinding of participants, clinicians and researchers will be conducted at trial sites in Australia and Sweden. Eligible participants will be randomised 1:1 into two groups. Intervention participants will receive ambulatory oxygen therapy using a portable oxygen concentrator (POC) during daily activities and control participants will use an identical POC modified to deliver air. Outcomes will be assessed at baseline, 3 months and 6 months. The primary outcome is change in physical activity measured by number of steps per day using a physical activity monitor (StepWatch). Secondary outcomes are functional capacity (6-minute walk distance), health-related quality of life (St George Respiratory Questionnaire, EQ-5D-5L and King's Brief Interstitial Lung Disease Questionnaire), breathlessness (Dyspnoea-12), fatigue (Fatigue Severity Scale), anxiety and depression (Hospital Anxiety and Depression Scale), physical activity level (GENEActive), oxygen saturation in daily life, POC usage, and plasma markers of skeletal muscle metabolism, systematic inflammation and oxidative stress. A cost-effectiveness evaluation will also be undertaken. Ethics and dissemination Ethical approval has been granted in Australia by Alfred Hospital Human Research Ethics Committee (HREC/18/Alfred/42) with governance approval at all Australian sites, and in Sweden (Lund Dnr: 2019-02963). The results will be published in peer-reviewed scientific journals, presented at conferences and disseminated to consumers in publications for lay audiences. Trial registration number ClinicalTrials.gov Registry (NCT03737409).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- clinical trials
- interstitial lung disease
- thoracic medicine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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BMJ Open
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Till lärosätets databas
- Av författaren/redakt...
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Holland, Anne E.
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Corte, Tamera
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Chambers, Daniel ...
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Palmer, Andrew J ...
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Ekström, Magnus ...
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Glaspole, Ian
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visa fler...
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Goh, Nicole S.L.
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Hepworth, Graham
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Khor, Yet H.
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Hoffman, Mariana
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Vlahos, Ross
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Sköld, Magnus
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Dowman, Leona
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Troy, Lauren K.
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Prasad, Jyotika ...
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Walsh, James
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McDonald, Christ ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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BMJ Open
- Av lärosätet
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Lunds universitet
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Karolinska Institutet