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Orthostatic Hypoten...
Orthostatic Hypotension Predicts Incidence of Heart Failure: The Malmö Preventive Project.
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- Fedorowski, Artur (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Hedblad, Bo (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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visa fler...
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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(creator_code:org_t)
- 2010-07-22
- 2010
- Engelska.
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Ingår i: American Journal of Hypertension. - : Oxford University Press (OUP). - 1941-7225 .- 0895-7061. ; 23, s. 1209-1215
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Abstract
Ämnesord
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- BackgroundThe presence of orthostatic hypotension (OH) predicts all-cause mortality and incident cardiovascular disease. Whether or not OH is associated with the development of heart failure (HF) remains unknown.MethodsIn this Swedish population-based prospective study (the Malmö Preventive Project), the incidence of HF in relation to baseline OH, defined as decrease in systolic (SBP) >/=20 mm Hg and/or diastolic blood pressure (DBP) >/=10 mm Hg upon standing, was studied in 32,669 middle-aged individuals (68.2% men; mean age, 45.6 +/- 7.4 years) over a mean follow-up period of 24 years.ResultsAt baseline, 1,991 (6.1%) participants were found to have OH. During follow-up, 1,293 persons (4.0%, mean age at presentation: 67.9 +/- 7.9 years) were hospitalized for HF, 912 (2.8%) of whom without previous or concurrent myocardial infarction (MI) ("nonischemic HF"). Among those who had OH, the corresponding numbers were 6.5% (n = 129) and 4.6% (n = 92), respectively. In multivariable Cox proportional hazard models, taking conventional HF risk factors into account, OH was associated with both all-cause and "nonischemic" HF events (hazard ratio (HR): 1.22, 1.01-1.46, and 1.31, 1.05-1.63, respectively). The association between OH and HF was more pronounced in younger (aged <45 years) than older individuals (2.05; 1.31-3.22 vs. 1.12, 0.92-1.38, respectively, P < 0.001 for interaction between age and OH on incident HF).ConclusionsThe presence of OH among middle-aged adults predicts long-term incidence of HF hospitalizations independently of conventional risk factors. Our findings add to the available data indicating that OH is a potential independent cardiovascular risk factor, especially with regard to younger individuals and nonischemic HF.American Journal of Hypertension (2010). doi:10.1038/ajh.2010.150.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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