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The Association Bet...
The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis : An Exploratory Study From the Osteoarthritis Initiative
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- Gong, Ze (författare)
- Northwestern Polytechnic University
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- Li, Shengfa (författare)
- Southern Medical University
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- Cao, Peihua (författare)
- Southern Medical University
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- Ruan, Guangfeng (författare)
- Southern Medical University
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- Zhang, Yan (författare)
- Southern Medical University
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- Zeng, Qing (författare)
- Southern Medical University
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- He, Zijun (författare)
- Southern Medical University
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- Li, Shilin (författare)
- Southern Medical University
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- Chen, Rong (författare)
- Southern Medical University
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- Zheng, Peng (författare)
- Southern Medical University
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- Fan, Tao (författare)
- Southern Medical University
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- Lu, Pengcheng (författare)
- Southern Medical University
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- Zhao, Yijin (författare)
- Southern Medical University
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- Englund, Martin (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Madry, Henning (författare)
- Saarland University Hospital
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- Huang, Guozhi (författare)
- Southern Medical University
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- Li, Le (författare)
- Northwestern Polytechnic University
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- Li, Jia (författare)
- Southern Medical University
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- Ding, Changhai (författare)
- Southern Medical University
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(creator_code:org_t)
- 2022-12-15
- 2023
- Engelska 8 s.
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Ingår i: The Journal of rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 50:4, s. 548-555
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA). METHODS: This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were included. Quadriceps strength was measured isometrically at baseline. Effusion-synovitis and Hoffa-synovitis were measured using the Magnetic Resonance Imaging Osteoarthritis Knee Score at baseline and at 1-year and 2-year follow-ups. Generalized estimating equations were used to analyze the associations of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis in multivariable analyses. Additionally, analyses were stratified by synovitis-driven inflammatory phenotypes. RESULTS: A total of 1513 knees were included in this study. In total, 61% of the subjects were female; subjects had an average age of 61.9 (SD 8.8) years and a mean BMI of 29.4 (SD 4.7). Regarding the whole population, baseline quadriceps strength was negatively associated with baseline effusion-synovitis and follow-up changes in effusion-synovitis (odds ratio [OR] 0.77-0.86), but no significant association was observed in terms of Hoffa-synovitis. Stratified by synovitis-driven inflammatory phenotype, baseline quadriceps strength was significantly associated with follow-up changes in effusion-synovitis-but not in Hoffa-synovitis-in the population with existing effusion-synovitis (OR 0.75-0.79). CONCLUSION: Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis-but not in Hoffa-synovitis-especially in the population with existing effusion-synovitis. Our findings suggested a potential protective role of the quadriceps in effusion-synovitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- effusion-synovitis
- Hoffa-synovitis
- osteoarthritis
- quadriceps
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gong, Ze
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Li, Shengfa
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Cao, Peihua
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Ruan, Guangfeng
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Zhang, Yan
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Zeng, Qing
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He, Zijun
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Li, Shilin
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Chen, Rong
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Zheng, Peng
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Fan, Tao
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Lu, Pengcheng
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Zhao, Yijin
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Englund, Martin
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Madry, Henning
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Huang, Guozhi
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Li, Le
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Li, Jia
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Ding, Changhai
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
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The Journal of r ...
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Lunds universitet