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Estimating glomerul...
Estimating glomerular filtration rate at the transition from pediatric to adult care
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- Pottel, Hans (författare)
- Catholic University of Leuven
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- Björk, Jonas (författare)
- Lund University,Lunds universitet,EPI@LUND,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Bökenkamp, Arend (författare)
- Academic Medical Center of University of Amsterdam (AMC),Emma Children’s Hospital,Vrije Universiteit Amsterdam
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- Berg, Ulla (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Åsling-Monemi, Kajsa (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Selistre, Luciano (författare)
- University of Caxias do Sul
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- Dubourg, Laurence (författare)
- Hôpital Edouard Herriot
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- Hansson, Magnus (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Littmann, Karin (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Jones, Ian (författare)
- Örebro University Hospital
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- Sjöström, Per (författare)
- Örebro University Hospital
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- Nyman, Ulf (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Delanaye, Pierre (författare)
- University of Liège Hospital,University of Liège
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Kidney International. - : Elsevier BV. - 0085-2538 .- 1523-1755. ; 95:5, s. 1234-1243
- Relaterad länk:
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http://dx.doi.org/10...
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https://orbi.uliege....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The current Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend the use of the bedside creatinine-based Chronic Kidney Disease in Children (CKiD) equation to estimate glomerular filtration rate (GFR) in children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in adults. However, this approach causes implausible changes in estimated GFR (eGFR) at the transition from pediatric to adult care. We investigated the performance of the KDIGO strategy and various creatinine-based eGFR equations in a cross-sectional dataset of 5,764 subjects (age 10-30 years), using directly measured GFR (mGFR) as reference. We also evaluated longitudinal GFR slopes in 136 subjects who transitioned to adult care. Implausible changes in eGFR resulted from the large overestimation (bias=+21 mL/min/1.73m 2 ) and poor precision of the CKD-EPI equation in the 18-20 year age group, compared to CKiD in the 16-18 year age group (bias=-2.7 mL/min/1.73m 2 ), resulting in a mean change of 23 mL/min/1.73m 2 at the transition to adult care. Averaging the CKiD and CKD-EPI estimates in young adults only partially mitigated this issue. The Full Age Spectrum equation (with and without height), the Lund-Malmö Revised equation, and an age-dependent weighted average of CKiD and CKD-EPI resulted in much smaller changes in eGFR at the transition (change of 0.6, -2.1, -0.9 and -1.8 mL/min/1.73m 2 , respectively). The longitudinal analysis revealed a significant difference in average GFR slope between mGFR and the KDIGO strategy (-2.2 vs. +2.9 mL/min/1.73 m 2 /year), which was not observed with the other approaches. These results suggest that the KDIGO recommendation for GFR estimation at the pediatric-adult care transition should be revisited.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- estimated GFR
- measured GFR
- pediatric-adult transition
- serum creatinine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Pottel, Hans
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Björk, Jonas
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Bökenkamp, Arend
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Berg, Ulla
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Åsling-Monemi, K ...
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Selistre, Lucian ...
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visa fler...
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Dubourg, Laurenc ...
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Hansson, Magnus
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Littmann, Karin
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Jones, Ian
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Sjöström, Per
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Nyman, Ulf
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Delanaye, Pierre
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Kidney Internati ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet