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Metabolic risk fact...
Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project
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- Lindkvist, Björn (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Johansen, Dorthe (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Stocks, Tanja (författare)
- Umeå universitet,Umeå University,Urologi och andrologi
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Concin, Hans (författare)
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Bjorge, Tone (författare)
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- Almquist, Martin (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Häggström, Christel (författare)
- Umeå universitet,Urologi och andrologi
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Engeland, Anders (författare)
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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Nagel, Gabriele (författare)
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- Jonsson, Håkan (författare)
- Umeå universitet,Onkologi
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Selmer, Randi (författare)
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Ulmer, Hanno (författare)
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Tretli, Steinar (författare)
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- Stattin, Pär (författare)
- Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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(creator_code:org_t)
- 2014-02-18
- 2014
- Engelska.
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Ingår i: BMC Cancer. - London : Springer Science and Business Media LLC. - 1471-2407. ; 14
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://bmccancer.bi...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related to other metabolic risk factors. We aimed to examine the risk of EAC and ESCC in relation to metabolic risk factors, separately and combined in a prospective cohort study. Methods: The Metabolic Syndrome and Cancer cohort includes prospective cohorts in Austria, Norway and Sweden, with blood pressure, lipids, glucose and BMI available from 578 700 individuals. Relative risk (RR) for EAC and ESCC was calculated using Cox's proportional hazards analysis for metabolic risk factors categorized into quintiles and transformed into z-scores. The standardized sum of all z-scores was used as a composite score for the metabolic syndrome (MetS). Results: In total, 324 histologically verified cases of esophageal cancer were identified (114 EAC, 184 ESCC and 26 with other histology). BMI was associated with an increased risk of EAC (RR 7.34 (95% confidence interval, 2.88-18.7) top versus bottom quintile) and negatively associated with the risk of ESCC (RR 0.38 (0.23-0.62)). The mean value of systolic and diastolic blood pressure (mid blood pressure) was associated with the risk of ESCC (RR 1.77 (1.37-2.29)). The composite MetS score was associated with the risk of EAC (RR 1.56 (1.19-2.05) per one unit increase of z-score) but not ESCC. Conclusions: In accordance with previous studies, high BMI was associated with an increased risk of EAC and a decreased risk of ESCC. An association between high blood pressure and risk of ESCC was observed but alcohol consumption is a potential confounding factor that we were not able to adjust for in the analysis. The MetS was associated with EAC but not ESCC. However this association was largely driven by the strong association between BMI and EAC. We hypothesize that this association is more likely to be explained by factors directly related to obesity than the metabolic state of the MetS, considering that no other metabolic factor than BMI was associated with EAC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Esophageal cancer
- Esophageal adenocarcinoma
- Esophageal squamous cell
- carcinoma
- Obesity
- Hypertension
- Esophageal cancer
- Esophageal cancer; Esophageal adenocarcinoma; Esophageal squamous cell carcinoma; Obesity; Hypertension
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Lindkvist, Björn
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Johansen, Dorthe
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Stocks, Tanja
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Concin, Hans
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Bjorge, Tone
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Almquist, Martin
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visa fler...
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Häggström, Chris ...
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Engeland, Anders
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Hallmans, Göran
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Nagel, Gabriele
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Jonsson, Håkan
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Selmer, Randi
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Ulmer, Hanno
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Tretli, Steinar
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Stattin, Pär
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Manjer, Jonas
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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BMC Cancer
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Umeå universitet
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Göteborgs universitet