Enantioselective synthesis of anti-beta-amido-alpha-hydroxy esters via asymmetric transfer hydrogenation coupled with dynamic kinetic resolution

• The asymmetric transfer hydrogenation of beta-amido-alpha-keto esters providing the corresponding anti-beta-amido-alpha-hydroxy esters via dynamic kinetic resolution is reported. The use of a commercially available, or simply prepared, chiral ruthenium catalyst results in good yields as well as high diastereoselectivities and enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Ruthenium

Dynamic kinetic resolution

Asymmetric transfer hydrogenation

Enantioselective

1

2-Amino alcohols

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