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Fracture strength o...
Fracture strength of the proximal femur injected with a calcium sulfate/hydroxyapatite bone substitute
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- Kok, Joeri (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Širka, Aurimas (författare)
- Lithuanian University of Health Sciences
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- Grassi, Lorenzo (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Raina, Deepak Bushan (författare)
- Lund University,Lunds universitet,Klinisk och experimentell benläkning,Forskargrupper vid Lunds universitet,Clinical and experimental bone healing,Lund University Research Groups
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- Tarasevičius, Šarūnas (författare)
- Lithuanian University of Health Sciences
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- Tägil, Magnus (författare)
- Lund University,Lunds universitet,Klinisk och experimentell benläkning,Forskargrupper vid Lunds universitet,Clinical and experimental bone healing,Lund University Research Groups
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- Lidgren, Lars (författare)
- Lund University,Lunds universitet,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Isaksson, Hanna (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska 7 s.
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Ingår i: Clinical Biomechanics. - : Elsevier BV. - 0268-0033. ; 63, s. 172-178
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Available interventions for preventing fragility hip fractures show limited efficacy. Injection of a biomaterial as bone substitute could increase the fracture strength of the hip. This study aimed to show the feasibility of injecting a calcium sulfate/hydroxyapatite based biomaterial in the femoral neck and to calculate the consequent change in strength using the finite element method. Methods: Five patients were injected with 10 ml calcium sulfate/hydroxyapatite in their femoral neck. Quantitative CT scans were taken before and after injection. Five additional patients with fragility hip fractures were also scanned and the images from the non-fractured contralateral sides were used. Finite element models were created for all proximal femora with and without injection and the models were tested under stance and sideways fall loading until fracture. The change in fracture strength caused by the injection was calculated. Additionally, perturbations in volume, location, and stiffness of the injected material were created to investigate their contribution to the fracture strength increase. Findings: The 10 ml injection succeeded in all patients. Baseline simulations showed theoretical fracture strength increases of 0–9%. Volume increase, change in location and increase in stiffness of the material led to increases in fracture strength of 1–27%, −8-26% and 0–17%, respectively. Altering the location of the injection to a more lateral position and increasing the stiffness of the material led to increases in fracture strength of up to 42%. Interpretation: This study shows that an injection of calcium sulfate/hydroxyapatite is feasible and can theoretically increase the hip's fracture strength.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Bone strength
- Ceramics
- Finite element analysis
- Hip fracture
- Osteoporosis
- Prophylactic injection
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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