Sökning: id:"swepub:oai:lup.lub.lu.se:28936efd-eebd-4cd3-a59f-71ee6b1ef51e" >
Residual insulin se...
Residual insulin secretion in individuals with type 1 diabetes in Finland : longitudinal and cross-sectional analyses
-
- Harsunen, Minna (författare)
- Folkhälsan Research Center,University of Helsinki
-
- Haukka, Jani (författare)
- Folkhälsan Research Center,University of Helsinki
-
- Harjutsalo, Valma (författare)
- Folkhälsan Research Center,University of Helsinki
-
visa fler...
-
- Mars, Nina (författare)
- Broad Institute,University of Helsinki
-
- Syreeni, Anna (författare)
- University of Helsinki,Folkhälsan Research Center
-
- Härkönen, Taina (författare)
- University of Helsinki
-
- Käräjämäki, Annemari (författare)
- University of Helsinki
-
- Ilonen, Jorma (författare)
- University of Turku
-
- Knip, Mikael (författare)
- University of Helsinki,Tampere University Hospital
-
- Sandholm, Niina (författare)
- Folkhälsan Research Center,University of Helsinki
-
- Miettinen, Päivi Johanna (författare)
- University of Helsinki
-
- Groop, Per Henrik (författare)
- Folkhälsan Research Center,University of Helsinki,Monash University
-
- Tuomi, Tiinamaija (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki,Folkhälsan Research Center
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska 9 s.
-
Ingår i: The Lancet Diabetes and Endocrinology. - 2213-8587. ; 11:7, s. 465-473
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, many individuals with type 1 diabetes have circulating C-peptide years after the diagnosis. We studied factors affecting random serum C-peptide concentration in individuals with type 1 diabetes and the association with diabetic complications. Methods: Our longitudinal analysis included individuals newly diagnosed with type 1 diabetes from Helsinki University Hospital (Helsinki, Finland) with repeated random serum C-peptide and concomitant glucose measurements from within 3 months of diagnosis and at least once later. The long-term cross-sectional analysis included data from participants from 57 centres in Finland who had type 1 diabetes diagnosed after 5 years of age, initiation of insulin treatment within 1 year from diagnosis, and a C-peptide concentration of less than 1·0 nmol/L (FinnDiane study) and patients with type 1 diabetes from the DIREVA study. We tested the association of random serum C-peptide concentrations and polygenic risk scores with one-way ANOVA, and association of random serum C-peptide concentrations, polygenic risk scores, and clinical factors with logistic regression. Findings: The longitudinal analysis included 847 participants younger than 16 years and 110 aged 16 years or older. In the longitudinal analysis, age at diagnosis strongly correlated with the decline in C-peptide secretion. The cross-sectional analysis included 3984 participants from FinnDiane and 645 from DIREVA. In the cross-sectional analysis, at a median duration of 21·6 years (IQR 12·5−31·2), 776 (19·4%) of 3984 FinnDiane participants had residual random serum C-peptide secretion (>0·02 nmol/L), which was associated with lower type 1 diabetes polygenic risk compared with participants without random serum C-peptide (p<0·0001). Random serum C-peptide was inversely associated with hypertension, HbA1c, and cholesterol, but also independently with microvascular complications (adjusted OR 0·61 [95% CI 0·38–0·96], p=0·033, for nephropathy; 0·55 [0·34–0·89], p=0·014, for retinopathy). Interpretation: Although children with multiple autoantibodies and HLA risk genotypes progressed to absolute insulin deficiency rapidly, many adolescents and adults had residual random serum C-peptide decades after the diagnosis. Polygenic risk of type 1 and type 2 diabetes affected residual random serum C-peptide. Even low residual random serum C-peptide concentrations seemed to be associated with a beneficial complications profile. Funding: Folkhälsan Research Foundation; Academy of Finland; University of Helsinki and Helsinki University Hospital; Medical Society of Finland; the Sigrid Juselius Foundation; the “Liv and Hälsa“ Society; Novo Nordisk Foundation; and State Research Funding via the Helsinki University Hospital, the Vasa Hospital District, Turku University Hospital, Vasa Central Hospital, Jakobstadsnejdens Heart Foundation, and the Medical Foundation of Vaasa.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Harsunen, Minna
-
Haukka, Jani
-
Harjutsalo, Valm ...
-
Mars, Nina
-
Syreeni, Anna
-
Härkönen, Taina
-
visa fler...
-
Käräjämäki, Anne ...
-
Ilonen, Jorma
-
Knip, Mikael
-
Sandholm, Niina
-
Miettinen, Päivi ...
-
Groop, Per Henri ...
-
Tuomi, Tiinamaij ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
The Lancet Diabe ...
- Av lärosätet
-
Lunds universitet