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Disposition of venl...
Disposition of venlafaxine enantiomers in rats with hepatic encephalopathy after chronic drug treatment.
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- Wikell, Cecilia (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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Eap, Chin B (författare)
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Josefsson, Martin (författare)
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Apelqvist, Gustav (författare)
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- Ahlner, Johan, 1949- (författare)
- Linköpings universitet,Hälsouniversitetet,Klinisk farmakologi
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Baumann, Pierre (författare)
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- Bengtsson, Finn, 1956- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk farmakologi
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(creator_code:org_t)
- 2002-04-11
- 2002
- Engelska.
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Ingår i: Chirality. - : Wiley. - 1520-636X .- 0899-0042. ; 14:4, s. 347-350
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Portacaval shunted (PCS) rats, a model of hepatic encephalopathy, and control animals were administered racemic venlafaxine for 14 days (10 mg/kg). The levels of the S- and R-enantiomers and the S/R-enantiomer ratios of venlafaxine and its metabolites were assessed by an enantiomer-selective chromatographic assay in serum, brain parenchyma, and brain dialysate of both groups. Higher levels of the S- and R-enantiomers of venlafaxine were found in serum and brain of PCS vs. normal rats (median values of S- and R-venlafaxine in serum: 290 and 201 nM in PCS; 97 and 66 nM in normal rats; median values of S- and R-venlafaxine in cortex: 956 and 939 nM in PCS; 357 and 318 nM in normal rats). Interestingly, similar S/R-venlafaxine ratios were observed in PCS and normal rats both in serum (S/R = 1.4) and brain compartments (S/R = l.0-1.1). These findings may have clinical relevance for the safety of venlafaxine in chronic hepatic encephalopathy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Cyclohexanols : administration & dosage
- Cyclohexanols : chemistry
- Cyclohexanols : pharmacokinetics
- Disease Models
- Animal
- Hepatic Encephalopathy : drug therapy
- Hepatic Encephalopathy : metabolism
- Human
- Male
- Portacaval Shunt
- Rats
- Surgical
- Sprague-Dawley
- Safety
- Stereoisomerism
- Brain : metabolism
- Second-Generation : pharmacokinetics
- Second-Generation : chemistry
- Antidepressive Agents
- Second-Generation : administration & dosage
- MEDICINE
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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