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Human TRPA1 is an i...
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel
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- Moparthi, Lavanya (författare)
- Linköpings universitet,Linköping University,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Wallenberg Centre for Molecular Medicine
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- Zygmunt, Peter M. (författare)
- Lund University,Lunds universitet,Neurofarmakologi och smärta,Forskargrupper vid Lunds universitet,Neuropharmacology and pain,Lund University Research Groups,Department of Clinical Sciences Malmö, Lund University, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Cell Calcium. - : Elsevier BV. - 0143-4160 .- 1532-1991. ; 91
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http://dx.doi.org/10... (free)
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Abstract
Ämnesord
Stäng
- The role of mammalian Transient Receptor Potential Ankyrin 1 (TRPA1) as a mechanosensor is controversial. Here, we report that purified human TRPA1 (hTRPA1) with and without its N-terminal ankyrin repeat domain responded with pressure-dependent single-channel current activity when reconstituted into artificial lipid bilayers. The hTRPA1 activity was abolished by the thiol reducing agent TCEP. Thus, depending on its redox state, hTRPA1 is an inherent mechanosensitive ion channel gated by force-from-lipids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Mechanosensation
- Mechanosensitive channel
- Redox sensitivity
- TRP channel
- TRPA1
- Mechanosensation; Mechanosensitive channel; Redox sensitivity; TRP channel; TRPA1
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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