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Protein kinase C in...
Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons
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- Wiklund, Peter (författare)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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- Ekström, Per (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Retinal degeneration: Molekylär patologi,Forskargrupper vid Lunds universitet,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Retinal degeneration: Molecular Pathology,Lund University Research Groups
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(creator_code:org_t)
- 1999
- 1999
- Engelska 4 s.
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Ingår i: Neuroscience Letters. - 0304-3940. ; 275:3, s. 155-158
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Abstract
Ämnesord
Stäng
- Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via other kinases. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Chelerythrine chloride
- Dorsal root ganglia
- Growth cones
- HA-1004
- Protein kinase A
- Protein kinase G
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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