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Immune modulation v...
Immune modulation via T regulatory cell enhancement : Disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)
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- Roth-Walter, Franziska (författare)
- University of Veterinary Medicine Vienna
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- Adcock, Ian M. (författare)
- Imperial College London
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- Benito-Villalvilla, Cristina (författare)
- Complutense University of Madrid
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- Bianchini, Rodolfo (författare)
- University of Veterinary Medicine Vienna
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- Bjermer, Leif (författare)
- Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups
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- Boyman, Onur (författare)
- University Hospital of Zurich,University of Zurich
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- Caramori, Gaetano (författare)
- University of Messina
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- Cari, Luigi (författare)
- University of Perugia
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- Fan Chung, Kian (författare)
- Imperial College London,Royal Brompton and Harefield NHS Foundation Trust
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- Diamant, Zuzana (författare)
- Skåne University Hospital,QPS-Netherlands,Thomayer Hospital,University Medical Center Groningen,University of Groningen,Charles University in Prague
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- Eguiluz-Gracia, Ibon (författare)
- Hospital Regional de Málaga
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- Knol, Edward F. (författare)
- University Medical Center Utrecht
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- Kolios, Antonios (författare)
- University Hospital of Zurich,University of Zurich
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- Levi-Schaffer, Francesca (författare)
- Hebrew University of Jerusalem
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- Nocentini, Giuseppe (författare)
- University of Perugia
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- Palomares, Oscar (författare)
- Complutense University of Madrid
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- Redegeld, Frank (författare)
- Utrecht University
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- Van Esch, Betty (författare)
- Utrecht University
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- Stellato, Cristiana (författare)
- University of Salerno
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(creator_code:org_t)
- 2021-01-07
- 2021
- Engelska 24 s.
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Ingår i: Allergy: European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538. ; 76:1, s. 90-113
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Therapeutic advances using targeted biologicals and small-molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune, and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen immunotherapy for selected allergic diseases, fail to change the disease course. T cell–based therapies aim to cure diseases through the selective induction of appropriate immune responses following the delivery of engineered, specific cytotoxic, or regulatory T cells (Tregs). Adoptive cell therapies (ACT) with genetically engineered T cells have revolutionized the oncology field, bringing curative treatment for leukemia and lymphoma, while therapies exploiting the suppressive functions of Tregs have been developed in nononcological settings, such as in transplantation and autoimmune diseases. ACT with Tregs are also being considered in nononcological settings such as cardiovascular disease, obesity, and chronic inflammatory disorders. After describing the general features of T cell–based approaches and current applications in autoimmune diseases, this position paper reviews the experimental models testing or supporting T cell–based approaches, especially Treg-based approaches, in severe IgE-mediated responses and chronic respiratory airway diseases, such as severe asthma and COPD. Along with an assessment of challenges and unmet needs facing the application of ACT in these settings, this article underscores the potential of ACT to offer curative options for patients with severe or treatment-resistant forms of these immune-driven disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- adoptive cell therapies
- allergy
- autoimmunity
- CAR-Treg cells
- immunoregulation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Roth-Walter, Fra ...
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Adcock, Ian M.
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Benito-Villalvil ...
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Bianchini, Rodol ...
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Bjermer, Leif
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Boyman, Onur
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visa fler...
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Caramori, Gaetan ...
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Cari, Luigi
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Fan Chung, Kian
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Diamant, Zuzana
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Eguiluz-Gracia, ...
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Knol, Edward F.
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Kolios, Antonios
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Levi-Schaffer, F ...
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Nocentini, Giuse ...
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Palomares, Oscar
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Redegeld, Frank
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Van Esch, Betty
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Stellato, Cristi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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Allergy: Europea ...
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Allergy
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