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Activatable MRI pro...
Activatable MRI probes for the specific detection of bacteria
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- Periyathambi, Prabu (författare)
- Linköpings universitet,Linköping University,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Wallenberg Centre for Molecular Medicine
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- Balian, Alien (författare)
- Linköpings universitet,Linköping University,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Wallenberg Centre for Molecular Medicine
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- Hu, Zhangjun (författare)
- Linköping University
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- Padro, Daniel (författare)
- Ctr Cooperat Res Biomat CIC BiomaGUNE, Spain
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- Hernandez, Luiza (författare)
- Linköpings universitet,Linköping University,Avdelningen för cellbiologi,Medicinska fakulteten
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- Uvdal, Kajsa (författare)
- Linköpings universitet,Linköping University,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Duarte, Joao (författare)
- Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Lund Univ, Sweden; Lund Univ, Sweden
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- Hernandez, Frank (författare)
- Linköpings universitet,Linköping University,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Wallenberg Centre for Molecular Medicine
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- Hu, Zhang-Jun (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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(creator_code:org_t)
- 2021-10-27
- 2021
- Engelska.
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Ingår i: Analytical and Bioanalytical Chemistry. - : Springer Science and Business Media LLC. - 1618-2642 .- 1618-2650. ; 413:30, s. 7353-7362
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Activatable fluorescent probes have been successfully used as molecular tools for biomedical research in the last decades. Fluorescent probes allow the detection of molecular events, providing an extraordinary platform for protein and cellular research. Nevertheless, most of the fluorescent probes reported are susceptible to interferences from endogenous fluorescence (background signal) and limited tissue penetration is expected. These drawbacks prevent the use of fluorescent tracers in the clinical setting. To overcome the limitation of fluorescent probes, we and others have developed activatable magnetic resonance probes. Herein, we report for the first time, an oligonucleotide-based probe with the capability to detect bacteria using magnetic resonance imaging (MRI). The activatable MRI probe consists of a specific oligonucleotide that targets micrococcal nuclease (MN), a nuclease derived from Staphylococcus aureus. The oligonucleotide is flanked by a superparamagnetic iron oxide nanoparticle (SPION) at one end, and by a dendron functionalized with several gadolinium complexes as enhancers, at the other end. Therefore, only upon recognition of the MRI probe by the specific bacteria is the probe activated and the MRI signal can be detected. This approach may be widely applied to detect bacterial infections or other human conditions with the potential to be translated into the clinic as an activatable contrast agent.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
Nyckelord
- Activatable MRI contrast agents
- Bacteria
- Detection system
- MRI
- Nucleases
- Nucleic acid probes
- MRI; Bacteria; Nucleic acid probes; Detection system; Nucleases; Activatable MRI contrast agents
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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