Sökning: id:"swepub:oai:lup.lub.lu.se:34bfdfba-8f6c-4480-93ef-d5f4bf31b625" >
Computational Desig...
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
-
King, Neil P. (författare)
-
Sheffler, William (författare)
-
Sawaya, Michael R. (författare)
-
visa fler...
-
Vollmar, Breanna S. (författare)
-
Sumida, John P. (författare)
-
- André, Ingemar (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
-
Gonen, Tamir (författare)
-
Yeates, Todd O. (författare)
-
Baker, David (författare)
-
visa färre...
-
(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2012
- 2012
- Engelska.
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 336:6085, s. 1171-1174
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to design a 24-subunit, 13-nm diameter complex with octahedral symmetry and a 12-subunit, 11-nm diameter complex with tetrahedral symmetry. The designed proteins assembled to the desired oligomeric states in solution, and the crystal structures of the complexes revealed that the resulting materials closely match the design models. The method can be used to design a wide variety of self-assembling protein nanomaterials.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
Science
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas