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The role of von Wil...
The role of von Willebrand factor in acute type A aortic dissection and aortic surgery
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- Zindovic, Igor (författare)
- Lund University,Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Forskargrupper vid Lunds universitet,Bleeding disorders and acute typ-A dissection,Lund University Research Groups,Skåne University Hospital
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- Sjögren, Johan (författare)
- Lund University,Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Forskargrupper vid Lunds universitet,Bleeding disorders and acute typ-A dissection,Lund University Research Groups,Skåne University Hospital
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- Bjursten, Henrik (författare)
- Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Less invasive cardiac surgery,Lund University Research Groups,Skåne University Hospital
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- Ingemansson, Richard (författare)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Larsson, Mårten (författare)
- Lund University,Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Forskargrupper vid Lunds universitet,Bleeding disorders and acute typ-A dissection,Lund University Research Groups,Skåne University Hospital
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- Svensson, Peter J. (författare)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital
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- Strandberg, Karin (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Wierup, Per (författare)
- Cleveland Clinic Foundation
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- Nozohoor, Shahab (författare)
- Lund University,Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Forskargrupper vid Lunds universitet,Bleeding disorders and acute typ-A dissection,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska 6 s.
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Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848. ; 178, s. 139-144
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Massive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). There are no previous reports evaluating the effect of ATAAD and associated surgery on von Willebrand factor (VWF). The aim of the present study was to analyze VWF activity (VWF:GPIbM) and thus the potential of Factor (F) VIII/VWF concentrate as a treatment for refractory bleeding in surgery for acute type A aortic dissection. Material and methods: We prospectively compared serial measurements of VWF:GPIbM in 25 patients with ATAAD to 20 control patients undergoing elective surgery of the ascending aorta or the aortic root. In 10 of the ATAAD patients, high molecular weight multimer distribution was measured. Results: Preoperatively, ATAAD patients demonstrated significantly higher VWF:GPIbM (1.58 (1.40–2.05) kIU/L vs 1.25 (1.02–1.42) kIU/L, p = 0.003). In the ATAAD group, VWF:GPIbM significantly decreased to 1.24 (0.98–1.44) kIU/L at lowest core temperature (T0 vs T1 p < 0.001), but remained unchanged in the elective group (1.25 (1.04–1.43) kIU/L, T0 vs T1 p < 0.625). Neither aortic dissection nor hypothermia caused any changes to the proportion of high molecular weight multimers when compared to control patients. Both groups demonstrated supernormal VWF:GPIbM on the first and fifth day after surgery. Conclusions: This report showed that patients with acute aortic dissection had increased levels of VWF:GPIbM before surgery that decreased slightly during surgery. Our study could not provide evidence that would encourage administration of FVIII/VWF concentrate for major bleeding in patients undergoing surgery for ATAAD as well as elective aortic procedures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Aorta
- Cardiac surgical procedures
- Dissection
- Hemorrhage
- von Willebrand factor
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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