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A randomized contro...
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults
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- Templeman, Iain (författare)
- University of Bath
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- Smith, Harry Alex (författare)
- University of Bath
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- Chowdhury, Enhad (författare)
- University of Bath
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- Chen, Yung Chih (författare)
- University of Bath,National Taiwan Normal University
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- Carroll, Harriet (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Bath
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- Johnson-Bonson, Drusus (författare)
- University of Bath
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- Hengist, Aaron (författare)
- University of Bath
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- Smith, Rowan (författare)
- University of Bath
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- Creighton, Jade (författare)
- University of Bath,Nottingham Trent University
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- Clayton, David (författare)
- Nottingham Trent University
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- Varley, Ian (författare)
- Nottingham Trent University
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Karagounis, Leonidas Georgios (författare)
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- Wilhelmsen, Andrew (författare)
- University of Nottingham
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- Tsintzas, Kostas (författare)
- University of Nottingham
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Reeves, Sue (författare)
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- Walhin, Jean Philippe (författare)
- University of Bath
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- Gonzalez, Javier Thomas (författare)
- University of Bath
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- Thompson, Dylan (författare)
- University of Bath
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- Betts, James Alexander (författare)
- University of Bath
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2021
- 2021
- Engelska.
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 13:598
- Relaterad länk:
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http://dx.doi.org/10...
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http://irep.ntu.ac.u...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healthy individuals (0:150; n = 12). Control groups involved a matched degree of energy restriction applied continuously without fasting (75% energy intake daily; 75:75; n = 12) or a matched pattern of fasting without net energy restriction (200% energy intake on alternate days; 0:200; n = 12). Primary outcomes were body composition, components of energy balance, and postprandial metabolism. Daily energy restriction (75:75) reduced body mass (-1.91 } 0.99 kilograms) almost entirely due to fat loss (-1.75 } 0.79 kilograms). Restricting energy intake via fasting (0:150) also decreased body mass (-1.60 } 1.06 kilograms; P = 0.46 versus 75:75) but with attenuated reductions in body fat (-0.74 } 1.32 kilograms; P = 0.01 versus 75:75), whereas fasting without energy restriction (0:200) did not significantly reduce either body mass (-0.52 } 1.09 kilograms; P ≤ 0.04 versus 75:75 and 0:150) or fat mass (-0.12 } 0.68 kilograms; P ≤ 0.05 versus 75:75 and 0:150). Postprandial indices of cardiometabolic health and gut hormones, along with the expression of key genes in subcutaneous adipose tissue, were not statistically different between groups (P >0.05). Alternate-day fasting less effectively reduces body fat mass than a matched degree of daily energy restriction and without evidence of fasting-specific effects on metabolic regulation or cardiovascular health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Templeman, Iain
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Smith, Harry Ale ...
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Chowdhury, Enhad
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Chen, Yung Chih
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Carroll, Harriet
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Johnson-Bonson, ...
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visa fler...
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Hengist, Aaron
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Smith, Rowan
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Creighton, Jade
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Clayton, David
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Varley, Ian
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Karagounis, Leon ...
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Wilhelmsen, Andr ...
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Tsintzas, Kostas
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Reeves, Sue
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Walhin, Jean Phi ...
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Gonzalez, Javier ...
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Thompson, Dylan
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Betts, James Ale ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Science Translat ...
- Av lärosätet
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Lunds universitet