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Vitamin D and infla...
Vitamin D and inflammation in major depressive disorder
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- Grudet, Cécile (författare)
- Lund University,Lunds universitet,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Unit for clinical suicide research,Lund University Research Groups
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- Wolkowitz, Owen M. (författare)
- University of California, San Francisco
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- Mellon, Synthia H. (författare)
- University of California, San Francisco
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- Malm, Johan (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Reus, Victor I. (författare)
- University of California, San Francisco
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- Brundin, Lena (författare)
- Van Andel Research Institute
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- Nier, Brenton M. (författare)
- University of California, San Francisco
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- Dhabhar, Firdaus S. (författare)
- University of Miami
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- Hough, Christina M. (författare)
- University of California, Los Angeles
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- Westrin, Åsa (författare)
- Lund University,Lunds universitet,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Unit for clinical suicide research,Lund University Research Groups,Region Skåne
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- Lindqvist, Daniel (författare)
- Lund University,Lunds universitet,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Unit for clinical suicide research,Lund University Research Groups,Unit for Biological and Precision Psychiatry,Region Skåne,University of California, San Francisco
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 9 s.
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327. ; 267, s. 33-41
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Increased inflammation is reported in Major Depressive Disorder (MDD), which may be more pronounced in suicidal subjects. Vitamin D deficiency may drive this pro-inflammatory state due to vitamin D's anti-inflammatory effects. Methods: We quantified plasma 25-hydroxyvitamin D (25(OH)D) and inflammatory markers interleukin (IL)-6 and tumor necrosis factor (TNF)-α, and other inflammatory indices, neutrophil-to-lymphocyte ratio (NLR) and white blood cell count (WBC) in 48 un-medicated MDD subjects (n = 17 with mild-to-moderate suicidal ideation [SI]) and 54 controls. IL-6 and TNF-α were combined into a composite inflammation score. Results: There were no significant differences in 25(OH)D levels between MDD and controls (p = 0.24) or between MDD with and without SI (p = 0.61). However, 25(OH)D was negatively correlated with all measured inflammatory markers; these correlations were stronger in MDD subjects, and particularly in those with SI. MDD status significantly moderated the relationships between 25(OH)D and NLR (p = 0.03), and 25(OH)D and WBC (p < 0.05), and SI significantly moderated the relationship between 25(OH)D and NLR (p = 0.03). Limitations: The study was cross-sectional, thereby limiting causal inference, and had a small sample size. Only seventeen of the MDD subjects had SI. Conclusion: While 25(OH)D levels did not significantly differ in MDD vs. controls, or in MDD with or without SI, lower 25(OH)D was associated with indices of immune activation in MDD, especially in cases with SI. Although our findings do not address causality, they are consistent with findings that relatively low 25(OH)D levels in MDD are associated with a pro-inflammatory state.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- 25(OH)D
- Inflammation
- Major depressive disorder
- Suicidal ideation
- Vitamin D
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Grudet, Cécile
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Wolkowitz, Owen ...
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Mellon, Synthia ...
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Malm, Johan
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Reus, Victor I.
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Brundin, Lena
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visa fler...
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Nier, Brenton M.
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Dhabhar, Firdaus ...
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Hough, Christina ...
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Westrin, Åsa
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Lindqvist, Danie ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Medicinska och f ...
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och Immunologi inom ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Psykiatri
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Journal of Affec ...
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Lunds universitet