Sökning: id:"swepub:oai:lup.lub.lu.se:3bd23a24-53eb-4b58-beb5-5ac7b334732e" >
Association of a mi...
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G > A genotype to insulin resistance
-
Nolsoe, RL (författare)
-
Hamid, YH (författare)
-
- Pociot, Flemming (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
-
visa fler...
-
Paulsen, S (författare)
-
Andersen, KM (författare)
-
Borch-Johnsen, K (författare)
-
Drivsholm, T (författare)
-
Hansen, T (författare)
-
Pedersen, O (författare)
-
Mandrup-Poulsen, T (författare)
-
visa färre...
-
(creator_code:org_t)
- 2006-05-04
- 2006
- Engelska.
-
Ingår i: Genes and Immunity. - : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 7:4, s. 316-321
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://www.nature.c...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Type II diabetes is caused by a failure of the pancreatic beta-cells to compensate for insulin resistance leading to hyperglycaemia. There is evidence for an essential role of an increased beta-cell apoptosis in type II diabetes. High glucose concentrations induce IL-1 beta production in human beta-cells, Fas expression and concomitant apoptosis owing to a constitutive expression of FasL. FASL and FAS map to loci linked to type II diabetes and estimates of insulin resistance, respectively. We have tested two functional promoter polymorphisms, FAS-670 G > A and FASL-844C > T as well as a microsatellite in the 3' UTR of FASL for association to type II diabetes in 549 type II diabetic patients and 525 normal-glucose-tolerant (NGT) control subjects. Furthermore, we have tested these polymorphisms for association to estimates of beta-cell function and insulin resistance in NGT subjects. We found significant association to type II diabetes for the allele distribution of the FASL microsatellite (P-value 0.02, Bonferroni corrected). The FAS-670G > A was associated with homeostasis model assessment insulin resistance index and body mass index (P-values 0.02 and 0.02). We conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- insulin
- resistance
- functional variants
- FASL
- type II diabetes
- FAS
- genetics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nolsoe, RL
-
Hamid, YH
-
Pociot, Flemming
-
Paulsen, S
-
Andersen, KM
-
Borch-Johnsen, K
-
visa fler...
-
Drivsholm, T
-
Hansen, T
-
Pedersen, O
-
Mandrup-Poulsen, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Annan klinisk me ...
- Artiklar i publikationen
-
Genes and Immuni ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet