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Sökning: id:"swepub:oai:lup.lub.lu.se:3c2443fc-f037-4884-b1a0-90945a11bc1f" > Discriminative accu...

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease

Pascoal, Tharick A. (författare)
McGill University Research Centre for Studies in Aging,University of Pittsburgh
Leuzy, Antoine (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
Therriault, Joseph (författare)
Montreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
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Chamoun, Mira (författare)
McGill University Research Centre for Studies in Aging,Montreal Neurological Institute & Hospital
Lussier, Firoza (författare)
University of Pittsburgh,McGill University Research Centre for Studies in Aging
Tissot, Cecile (författare)
Lund University,University of Pittsburgh
Strandberg, Olof (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
Palmqvist, Sebastian (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
Stomrud, Erik (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
Ferreira, Pamela C.L. (författare)
University of Pittsburgh
Ferrari-Souza, João Pedro (författare)
Federal University of Rio Grande do Sul,University of Pittsburgh
Smith, Ruben (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
Benedet, Andrea Lessa (författare)
McGill University Research Centre for Studies in Aging,Montreal Neurological Institute & Hospital
Gauthier, Serge (författare)
McGill University Research Centre for Studies in Aging
Hansson, Oskar (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
Rosa-Neto, Pedro (författare)
McGill University Research Centre for Studies in Aging,Montreal Neurological Institute & Hospital
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 (creator_code:org_t)
2023-01-30
2023
Engelska.
Ingår i: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - : Wiley. - 2352-8729. ; 15:1
Relaterad länk:
http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

A/T/N system
Alzheimer's disease
biomarker
diagnose
PET

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art (ämneskategori)
ref (ämneskategori)

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