Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age

• Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in combination with other factors, was the most significant predictor of MND-2. The association found between abnormal fetal aortic velocity waveforms and adverse outcome in terms of minor neurological dysfunction suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal neurological development.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

Analysis of Variance

Aorta, Thoracic/diagnostic imaging

Blood Flow Velocity

Child

Child Development

Female

Fetal Growth Retardation/complications

Fetal Heart/physiopathology

Hemodynamics/physiology

Humans

Infant, Newborn

Infant, Small for Gestational Age

Logistic Models

Longitudinal Studies

Nervous System Diseases/diagnosis

Predictive Value of Tests

Pregnancy

Prospective Studies

Risk Factors

Ultrasonography, Prenatal

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)