Sökning: id:"swepub:oai:lup.lub.lu.se:40a090dd-cf3d-442a-820e-a540a262b655" >
Stretch increases a...
Stretch increases alveolar type 1 cell number in fetal lungs through ROCK-Yap/Taz pathway
-
- Nguyen, Tram Mai (författare)
- Catholic University of Leuven
-
- van der Merwe, Johannes (författare)
- Catholic University of Leuven
-
- Elowsson Rendin, Linda (författare)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups
-
visa fler...
-
- Larsson-Callerfelt, Anna Karin (författare)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups
-
- Deprest, Jan (författare)
- University Hospitals Leuven,Catholic University of Leuven,University College London
-
- Westergren-Thorsson, Gunilla (författare)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups
-
- Toelen, Jaan (författare)
- University Hospitals Leuven,Catholic University of Leuven
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2021
- 2021
- Engelska.
-
Ingår i: American journal of physiology. Lung cellular and molecular physiology. - : American Physiological Society. - 1522-1504 .- 1040-0605. ; 321:5, s. 814-826
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://journals.phy...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. Despite our growing understanding of the role of physical forces in lung development, the molecular mechanisms that regulate the transduction of mechanical stretch to alveolar differentiation remain elusive. To simulate lung distension, we optimized both an ex vivo model with precision cut lung slices and an in vivo model of fetal tracheal occlusion. Increased mechanical tension showed to improve alveolar maturation and differentiation toward AT1. By manipulating ROCK pathway, we demonstrate that stretch-induced Yap/Taz activation promotes alveolar differentiation toward AT1 phenotype via ROCK activity. Our findings show that balanced ROCK-Yap/Taz signaling is essential to regulate AT1 differentiation in response to mechanical stretching of the fetal lung, which might be helpful in improving lung development and regeneration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- alveolar cell type 1
- lung mechanotransduction
- ROCK pathway
- tracheal occlusion
- Yap/Taz
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas