Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjogren's syndrome

• Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjogren's syndrome ( pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American - European Consensus Criteria ( AECC), and 30 age- and sex- matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [ calculating the expiration/ inspiration ( E/ I) ratio] and the finger skin blood flow test [ the vasoconstriction ( VAC) index]. Results: pSS patients experienced significantly more dysphagia compared with controls ( 65% vs. 3%; p < 0.001). Pharyngeal ( 45% vs. 7%; p < 0.01), oesophageal ( 80% vs. 7%; p < 0.001) and gastro- oesophageal reflux symptoms ( 60% vs. 23%; p < 0.01) were also more prevalent in pSS patients compared with controls while pharyngeal ( 15% vs. 17%; p=NS) and oesophageal dysmotility ( 40% vs. 30%; p=NS) were not. Dysphagia was not associated with dysmotility but was found to be associated with a decreased E/ I ratio [ -1.05 ( -1.51 to -0.40) in patients with dysphagia vs. -0.21 ( -0.39 to 0.65) in patients without dysphagia; p < 0.01]. Conclusion: Subjective swallowing difficulties were more common in pSS patients than in controls while objective signs of pharyngeal and oesophageal dysmotility were not. Dysphagia in pSS patients does not seem to be related to video radiographical signs of dysmotility but may be related to an impaired parasympathetic function.

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MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

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