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The performance of ...
The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer's disease : a literature review
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- Brand, Abby L. (författare)
- Washington University in St. Louis
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- Lawler, Paige E. (författare)
- Washington University in St. Louis
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- Bollinger, James G. (författare)
- Washington University in St. Louis
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- Li, Yan (författare)
- Washington University in St. Louis
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- Schindler, Suzanne E. (författare)
- Washington University in St. Louis
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- Li, Melody (författare)
- Washington University in St. Louis
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- Lopez, Samir (författare)
- Washington University in St. Louis
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- Ovod, Vitaliy (författare)
- Washington University in St. Louis
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- Nakamura, Akinori (författare)
- Nagoya University,National Center for Geriatrics and Gerontology
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- Shaw, Leslie M. (författare)
- University of Pennsylvania
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- Zetterberg, Henrik (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Klinisk minnesforskning,Neurobiology,Lund University Research Groups,Clinical Memory Research,Skåne University Hospital
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- Bateman, Randall J. (författare)
- Washington University in St. Louis
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Washington University in St Louis Nagoya University (creator_code:org_t)
- 2022-12-27
- 2022
- Engelska 1 s.
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Ingår i: Alzheimer's Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 14:1, s. 195-195
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Abstract
Ämnesord
Stäng
- The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD). Detection of Aβ pathology is essential for AD diagnosis and for identifying and recruiting research participants for clinical trials evaluating disease-modifying therapies. Currently, AD diagnoses are usually made by clinical assessments, although detection of AD pathology with positron emission tomography (PET) scans or cerebrospinal fluid (CSF) analysis can be used by specialty clinics. These measures of Aβ aggregation, e.g. plaques, protofibrils, and oligomers, are medically invasive and often only available at specialized medical centers or not covered by medical insurance, and PET scans are costly. Therefore, a major goal in recent years has been to identify blood-based biomarkers that can accurately detect AD pathology with cost-effective, minimally invasive procedures.To assess the performance of plasma Aβ assays in predicting amyloid burden in the central nervous system (CNS), this review compares twenty-one different manuscripts that used measurements of 42 and 40 amino acid-long Aβ (Aβ42 and Aβ40) in plasma to predict CNS amyloid status. Methodologies that quantitate Aβ42 and 40 peptides in blood via immunoassay or immunoprecipitation-mass spectrometry (IP-MS) were considered, and their ability to distinguish participants with amyloidosis compared to amyloid PET and CSF Aβ measures as reference standards was evaluated. Recent studies indicate that some IP-MS assays perform well in accurately and precisely measuring Aβ and detecting brain amyloid aggregates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Amyloid beta
- Amyloidosis
- Biomarker
- Blood
- Plasma
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Brand, Abby L.
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Lawler, Paige E.
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Bollinger, James ...
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Li, Yan
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Schindler, Suzan ...
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Li, Melody
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visa fler...
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Lopez, Samir
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Ovod, Vitaliy
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Nakamura, Akinor ...
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Shaw, Leslie M.
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Zetterberg, Henr ...
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Hansson, Oskar
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Bateman, Randall ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Alzheimer's Rese ...
- Av lärosätet
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Lunds universitet
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Göteborgs universitet