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A multisubstrate de...
A multisubstrate deoxyribonucleoside kinase from plants.
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- Clausen, Anders Ranegaard (author)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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Girandon, Lenart (author)
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- Knecht, Wolfgang (author)
- Technical University of Denmark
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- Survery, Sabeen (author)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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- Andreasson, Erik (author)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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Munch-Petersen, Birgitte (author)
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- Piskur, Jure (author)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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(creator_code:org_t)
- Oxford University Press (OUP), 2008
- 2008
- English.
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In: Nucleic acids symposium series. - : Oxford University Press (OUP). - 0261-3166 .- 1746-8272. ; :52, s. 489-490
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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