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Monoclonal gammopat...
Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study
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- Kristinsson, Sigurdur Y. (författare)
- Karolinska Institutet
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Tang, Min (författare)
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Pfeiffer, Ruth M. (författare)
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- Bjorkholm, Magnus (författare)
- Karolinska Institutet
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Goldin, Lynn R. (författare)
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Blimark, Cecilie (författare)
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Mellqvist, Ulf-Henrik (författare)
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- Wahlin, Anders (författare)
- Umeå universitet,Onkologi
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- Turesson, Ingemar (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Landgren, Ola (författare)
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(creator_code:org_t)
- 2011-12-16
- 2012
- Engelska.
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 97:6, s. 854-858
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P < 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- monoclonal gammopathy of undetermined significance
- infections
- multiple
- myeloma
- bacteria
- virus
- MGUS
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kristinsson, Sig ...
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Tang, Min
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Pfeiffer, Ruth M ...
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Bjorkholm, Magnu ...
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Goldin, Lynn R.
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Blimark, Cecilie
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visa fler...
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Mellqvist, Ulf-H ...
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Wahlin, Anders
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Turesson, Ingema ...
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Landgren, Ola
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Haematologica
- Av lärosätet
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Lunds universitet
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Umeå universitet
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Karolinska Institutet