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Statin therapy is a...
Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
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- Schrader, Silja (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital,Lund Univ, Scania Univ Hosp, Diabet Ctr, Dept Clin Sci,Epigenet & Diabet Unit, S-20502 Malmö, Sweden.
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- Perfilyev, Alexander (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital,Lund Univ, Scania Univ Hosp, Diabet Ctr, Dept Clin Sci,Epigenet & Diabet Unit, S-20502 Malmö, Sweden.
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- Martinell, Mats, 1971- (författare)
- Uppsala universitet,Uppsala University,Allmänmedicin och preventivmedicin
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visa fler...
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- García-Calzón, Sonia (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,University of Navarra,Skåne University Hospital,Lund Univ, Scania Univ Hosp, Diabet Ctr, Dept Clin Sci,Epigenet & Diabet Unit, S-20502 Malmö, Sweden.;Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
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- Ling, Charlotte (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital,Lund Univ, Scania Univ Hosp, Diabet Ctr, Dept Clin Sci,Epigenet & Diabet Unit, S-20502 Malmö, Sweden.
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(creator_code:org_t)
- Future Medicine Ltd, 2021
- 2021
- Engelska 7 s.
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Ingår i: Epigenomics. - : Future Medicine Ltd. - 1750-1911 .- 1750-192X. ; 13:12, s. 919-925
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular disease
- causal mediation analyses
- DNA methylation
- epigenetics
- HDL
- LDL
- pharmacoepigenetics
- statins
- therapy
- Type 2 diabetes
- ANDIS
- diabetes
- cardiovascular disease
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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