Rat alpha 1-microglobulin : co-expression in liver with the light chain of inter-alpha-trypsin inhibitor

• A 1162 bp rat liver cDNA clone encoding the immunoregulatory plasma protein alpha 1-microglobulin was isolated and sequenced. The open reading frame encoded a 349 amino acid polyprotein, including alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasma protein inter-alpha-trypsin inhibitor, 145 amino acids. The alpha 1-microglobulin/bikunin mRNA was found only in the liver when different tissues were examined. Free alpha 1-microglobulin and a polyprotein, containing both alpha 1-microglobulin and inter-alpha-trypsin inhibitor epitopes, were found in the microsomal fraction from rat liver homogenates.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Alpha-Globulins/chemistry

Amino Acid Sequence

Animals

Base Sequence

Cloning, Molecular

Glycoproteins/chemistry

Liver/metabolism

Membrane Glycoproteins

Molecular Sequence Data

Protein Precursors/chemistry

RNA, Messenger/genetics

Rats

Rats, Inbred Strains

Trypsin Inhibitor, Kunitz Soybean

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)