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Microglia Protect N...
Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor
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Lambertsen, Kate Lykke (författare)
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Clausen, Bettina Hjelm (författare)
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Babcock, Alicia Anne (författare)
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Gregersen, Rikke (författare)
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Fenger, Christina (författare)
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Nielsen, Helle Hvilsted (författare)
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Haugaard, Laila Skov (författare)
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Wirenfeldt, Martin (författare)
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Nielsen, Marianne (författare)
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Dagnaes-Hansen, Frederik (författare)
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Bluethmann, Horst (författare)
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Faergeman, Nils Joakim (författare)
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Meldgaard, Michael (författare)
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- Deierborg, Tomas (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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Finsen, Bente (författare)
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: The Journal of Neuroscience. - 1529-2401. ; 29:5, s. 1319-1330
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Microglia and infiltrating leukocytes are considered major producers of tumor necrosis factor (TNF), which is a crucial player in cerebral ischemia and brain inflammation. We have identified a neuroprotective role for microglial-derived TNF in cerebral ischemia in mice. We show that cortical infarction and behavioral deficit are significantly exacerbated in TNF-knock-out (KO) mice compared with wild-type mice. By using in situ hybridization, immunohistochemistry, and green fluorescent protein bone marrow (BM)-chimeric mice, TNF was shown to be produced by microglia and infiltrating leukocytes. Additional analysis demonstrating that BM-chimeric TNF-KO mice grafted with wild-type BM cells developed larger infarcts than BM-chimeric wild-type mice grafted with TNF-KO BM cells provided evidence that the neuroprotective effect of TNF was attributable to microglial-not leukocyte-derived TNF. In addition, observation of increased infarction in TNF-p55 receptor (TNF-p55R)-KO mice compared with TNF-p75R and wild-type mice suggested that microglial-derived TNF exerts neuroprotective effects through TNF-p55R. We finally report that TNF deficiency is associated with reduced microglial population size and Toll-like receptor 2 expression in unmanipulated brain, which might also influence the neuronal response to injury. Our results identify microglia and microglial-derived TNF as playing a key role in determining the survival of endangered neurons in cerebral ischemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- neuroprotection
- chimeric mice
- knock-out mice
- cytokines
- neurodegeneration
- behavior
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lambertsen, Kate ...
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Clausen, Bettina ...
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Babcock, Alicia ...
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Gregersen, Rikke
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Fenger, Christin ...
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Nielsen, Helle H ...
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visa fler...
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Haugaard, Laila ...
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Wirenfeldt, Mart ...
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Nielsen, Mariann ...
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Dagnaes-Hansen, ...
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Bluethmann, Hors ...
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Faergeman, Nils ...
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Meldgaard, Micha ...
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Deierborg, Tomas
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Finsen, Bente
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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The Journal of N ...
- Av lärosätet
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Lunds universitet