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Platelet mitochondr...
Platelet mitochondrial DNA methylation : A novel biomarker for myocardial infarction – A preliminary study
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- Peng, Ningxin (author)
- Nanjing University
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- Guo, Liqiong (author)
- Tianjin University
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- Wei, Zhonghai (author)
- Nanjing University
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- Wang, Xiao (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Center for Primary Health Care Research
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- Zhao, Lei (author)
- Tianjin University
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- Kang, Lina (author)
- Nanjing University
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- Wang, Kun (author)
- Nanjing University
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- Zhou, Weihong (author)
- Nanjing University
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- Cheng, Shoujun (author)
- Nanjing University
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- Yin, Songjiang (author)
- Nanjing University of Chinese Medicine
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- Xu, Biao (author)
- Nanjing University
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- Bao, Xue (author)
- Nanjing University
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: International Journal of Cardiology. - 0167-5273.
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: Platelet activation and thrombus formation play critical roles in the pathogenesis of myocardial infarction (MI). In addition to their role in energy production, platelet mitochondria also regulate cellular functions related to apoptosis, oxidative stress, and inflammation. Epigenetic modifications of platelet mitochondrial DNA (mtDNA) may influence platelet function and are believed to be an important factor in MI. Therefore, the aim of this study was to investigate the differences in platelet mtDNA methylation levels between MI patients and controls. Methods: The present study utilized propensity score matching to generate 45 multivariate matched apparently healthy controls for 45 patients with newly-onset acute MI. Platelet mtDNA methylation levels were assessed through bisulfite-PCR pyrosequencing and compared between the two groups, with further adjustments made in the sensitivity analysis. Results: Among the measured mitochondrial genes (MT-COX1, MT-COX2, MT-COX3, MT-ND5, MT-ATP6 and tRNA_Leu), patients with MI exhibited statistically significant differences in mtDNA methylation levels as compared to matched controls. Specifically, higher levels of mtDNA methylation were observed in MT-COX1, MT-COX3, and tRNA_Leu, while a lower level was observed in MT-ATP6 (all p < 0.0001). These results remained robust in the sensitivity analysis. Conclusion: Our study demonstrated significant variations in platelet mtDNA methylation levels between patients with MI and controls. Platelet mtDNA methylation may serve as a novel biomarker for MI. This observation also provided some insights into the etiology of MI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Mitochondrial DNA methylation
- Myocardial infarction
- Platelet
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Peng, Ningxin
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Guo, Liqiong
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Wei, Zhonghai
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Wang, Xiao
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Zhao, Lei
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Kang, Lina
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show more...
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Wang, Kun
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Zhou, Weihong
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Cheng, Shoujun
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Yin, Songjiang
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Xu, Biao
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Bao, Xue
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Lund University