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Letter to the edito...
Letter to the editor : Indacaterol/glycopyrronium/mometasone furoate compared with salmeterol/fluticasone propionate in patients with asthma: A randomized controlled cross-over study
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- Watz, Henrik (författare)
- LungenClinic Grosshansdorf,German Center for Lung Research (DZL)
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- Hohlfeld, Jens M. (författare)
- German Center for Lung Research (DZL),Fraunhofer Institute for Toxicology and Experimental Medicine,Hannover Medical School
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- Singh, Dave (författare)
- Manchester University NHS Foundation Trust,University of Manchester
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- Beier, Jutta (författare)
- Institut für Atemwegsforschung GmbH
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- Diamant, Zuzana (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,QPS-Netherlands,Skåne University Hospital
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- Liu, Jinming (författare)
- Shanghai Pulmonary Hospital
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- Hua, Shucheng (författare)
- The First Bethune Hospital of Jilin University
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- Abd-Elaziz, Khalid (författare)
- QPS-Netherlands
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- Pinot, Pascale (författare)
- Novartis Pharma AG
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- Jones, Ieuan (författare)
- Novartis Pharma AG
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- Tillmann, Hanns Christian (författare)
- Novartis Pharma AG
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(creator_code:org_t)
- 2020-04-15
- 2020
- Engelska.
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Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 21:1
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http://dx.doi.org/10... (free)
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Abstract
Ämnesord
Stäng
- Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatment delivered via the Breezhaler® device for the treatment of patients with asthma. In this randomized (n = 116), double-blind, double-dummy, active comparator-controlled, three-period cross-over study we evaluated the benefit of o.d. IND/GLY/MF versus twice daily (b.i.d.) salmeterol/fluticasone propionate combination (SFC; 50/500 μg; high-dose ICS) treatment (NCT03063086). Overall, 107 patients completed the study. The study met its primary objective by demonstrating superiority of o.d. IND/GLY/MF at medium and high-dose ICS over b.i.d. SFC (high-dose ICS) in peak FEV1 after 21 days of treatment (+ 172 mL with high-dose and + 159 mL with medium-dose IND/GLY/MF versus SFC, p < 0.0001 for each comparison). We also observed that a higher percentage of patients did not need rescue medicine with IND/GLY/MF (high-dose ICS, 58%; medium-dose ICS, 52%) compared with SFC (45%) during the last week of each treatment period. Study treatments were well-tolerated with no relevant differences in tolerability between both IND/GLY/MF doses and SFC. In conclusion, both doses of IND/GLY/MF provided superior lung function benefits compared with twice-daily, standard-of-care SFC at the highest approved dose.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Asthma
- Glycopyrronium
- Indacaterol
- Mometasone Furoate
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Watz, Henrik
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Hohlfeld, Jens M ...
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Singh, Dave
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Beier, Jutta
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Diamant, Zuzana
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Liu, Jinming
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visa fler...
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Hua, Shucheng
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Abd-Elaziz, Khal ...
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Pinot, Pascale
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Jones, Ieuan
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Tillmann, Hanns ...
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