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PRDM10 -rearranged ...
PRDM10 -rearranged Soft Tissue Tumor : A Clinicopathologic Study of 9 Cases
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- Puls, Florian (författare)
- University College London,Sahlgrenska University Hospital
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- Pillay, Nischalan (författare)
- Royal National Orthopedic Hospital
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- Fagman, Henrik (författare)
- Sahlgrenska University Hospital
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- Palin-Masreliez, Anne (författare)
- Sahlgrenska University Hospital
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- Amary, Fernanda (författare)
- Royal National Orthopedic Hospital
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- Hansson, Magnus (författare)
- Sahlgrenska University Hospital
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- Kindblom, Lars Gunnar (författare)
- Sahlgrenska University Hospital
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- McCulloch, Tom A. (författare)
- Nottingham City Hospital
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- Meligonis, George (författare)
- Addenbrooke's Hospital
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- Muc, Ronald (författare)
- Birmingham Heartlands Hospital
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- Rissler, Pehr (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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Sumathi, Vaiyapuri P. (författare)
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Tirabosco, Roberto (författare)
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- Hofvander, Jakob (författare)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
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- Magnusson, Linda (författare)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
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- Nilsson, Jenny (författare)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
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- Flanagan, Adrienne M. (författare)
- Royal National Orthopedic Hospital
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- Mertens, Fredrik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,The genetics of soft tissue tumors,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2019
- 2019
- Engelska.
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Ingår i: American Journal of Surgical Pathology. - 0147-5185. ; 43:4, s. 504-513
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). Here, we describe the morphologic and clinical features of 9 such tumors from 5 men and 4 women (age: 20 to 61 y). Three cases had previously been diagnosed as UPS, 3 as superficial CD34-positive fibroblastic tumor (SCD34FT), 2 as pleomorphic liposarcoma, and 1 as pleomorphic hyalinizing angiectatic tumor. The tumors were located in the superficial and deep soft tissues of the thigh/knee region (4 cases), shoulder (2 cases), foot, trunk, and perineum (1 case each) ranging in size from 1 to 6 cm. All showed poorly defined cellular fascicles of pleomorphic cells within a fibrous stroma with frequent myxoid change and a prominent inflammatory infiltrate. All displayed highly pleomorphic nuclear features, but a low mitotic count. Most tumors were well circumscribed. One of 9 tumors recurred locally, but none metastasized. Immunohistochemically, all were CD34+ and showed nuclear positivity for PRDM10; focal positivity for cytokeratins was seen in 5/6 cases. PRDM10 immunoreactivity was evaluated in 50 soft tissue tumors that could mimic PRDM10- rearranged tumors, including 4 cases exhibiting histologic features within the spectrum of SCD34FT. Except for 2/6 pleomorphic liposarcomas and 1/4 myxofibrosarcomas, other tumors did not show nuclear positivity but displayed weak to moderate cytoplasmic immunoreactivity. In conclusion, PRDM10-rearranged soft tissue tumor is characterized by pleomorphic morphology and a low mitotic count. Its morphologic spectrum overlaps with SCD34FT. Clinical features of this small series suggest an indolent behavior, justifying its distinction from UPS and other sarcomas.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- immunohistochemistry
- PRDM10
- sarcoma
- superficial CD34-positive fibroblastic tumor
- translocation-associated sarcoma
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Puls, Florian
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Pillay, Nischala ...
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Fagman, Henrik
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Palin-Masreliez, ...
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Amary, Fernanda
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Hansson, Magnus
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visa fler...
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Kindblom, Lars G ...
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McCulloch, Tom A ...
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Meligonis, Georg ...
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Muc, Ronald
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Rissler, Pehr
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Sumathi, Vaiyapu ...
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Tirabosco, Rober ...
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Hofvander, Jakob
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Magnusson, Linda
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Nilsson, Jenny
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Flanagan, Adrien ...
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Mertens, Fredrik
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Lunds universitet