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Late mortality amon...
Late mortality among survivors of childhood acute lymphoblastic leukemia diagnosed during 1971–2008 in Denmark, Finland, and Sweden : A population-based cohort study
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- Sørensen, Gitte V. (författare)
- Aarhus University Hospital
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- Belmonte, Federica (författare)
- Danish Cancer Society
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- Erdmann, Friederike (författare)
- Danish Cancer Society,Universitätsmedizin Mainz
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- Mogensen, Hanna (författare)
- Karolinska Institutet,Karolinska Institute
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- Albieri, Vanna (författare)
- Danish Cancer Society
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- Holmqvist, Anna S. (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Madanat-Harjuoja, Laura (författare)
- Finnish Cancer Registry
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- Talbäck, Mats (författare)
- Karolinska Institutet,Karolinska Institute
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- Heyman, Mats M. (författare)
- Karolinska Institute
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- Malila, Nea (författare)
- Finnish Cancer Registry
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- Feychting, Maria (författare)
- Karolinska Institutet,Universitätsmedizin Mainz
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- Schmiegelow, Kjeld (författare)
- University of Copenhagen
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- Winther, Jeanette F. (författare)
- Danish Cancer Society,Aarhus University Hospital
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- Hasle, Henrik (författare)
- Aarhus University Hospital
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(creator_code:org_t)
- 2021-09-28
- 2022
- Engelska.
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Ingår i: Pediatric Blood and Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 69:1
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: Investigate all-cause and cause-specific late mortality after childhood acute lymphoblastic leukemia (ALL) in a population-based Nordic cohort. Methods: From the cancer registries of Denmark, Finland, and Sweden, we identified 3765 five-year survivors of ALL, diagnosed before age 20 during 1971–2008. For each survivor, up to five matched comparison subjects were randomly selected from the general population (n = 18,323). Causes of death were classified as relapse related, health related, and external. Late mortality was evaluated by cumulative incidences of death from 5-year survival date. Mortality hazard ratios (HR) were evaluated with Cox proportional models. Results: Among the survivors, 315 deaths occurred during a median follow-up of 16 years from 5-year survival date (range 0–42). The majority were attributable to relapse (n = 224), followed by second neoplasm (n = 45). Cumulative incidence of all-cause late mortality at 15 years from diagnosis decreased gradually over treatment decades, from 14.4% (95% confidence interval [CI]: 11.6–17.2) for survivors diagnosed during 1971–1981, to 2.5% (95% CI: 1.3–3.7) for those diagnosed during 2002–2008. This was mainly attributable to a reduction in relapse-related deaths decreasing from 13.4% (95% CI: 10.7–16.1) for survivors diagnosed during 1971–1981 to 1.9% (95% CI: 0.9–2.8) for those diagnosed during 2002–2008. Health-related late mortality was low and did not change substantially across treatment decades. Compared to comparison subjects, all-cause mortality HR was 40 (95% CI: 26–61) 5–9 years from diagnosis, and 4.4 (95% CI: 3.4–5.6) ≥10 years from diagnosis. Conclusions: Survivors of ALL have higher late mortality than population comparison subjects. Among the survivors, there was a temporal reduction in risk of death from relapse, without increments in health-related death.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- acute lymphoblastic leukemia
- cause-specific mortality
- childhood cancer
- late mortality
- long-term follow-up
- survivorship
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sørensen, Gitte ...
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Belmonte, Federi ...
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Erdmann, Frieder ...
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Mogensen, Hanna
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Albieri, Vanna
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Holmqvist, Anna ...
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Madanat-Harjuoja ...
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Talbäck, Mats
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Heyman, Mats M.
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Malila, Nea
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Feychting, Maria
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Schmiegelow, Kje ...
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Winther, Jeanett ...
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Hasle, Henrik
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Pediatric Blood ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet