Sökning: id:"swepub:oai:lup.lub.lu.se:50d6a367-5ed8-43d5-9ea8-d2294e108a23" >
Measurement of alph...
Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
-
Olsson, A (författare)
-
Hoglund, K (författare)
-
Sjogren, M (författare)
-
visa fler...
-
- Andreasen, N (författare)
- Karolinska Institutet
-
- Minthon, Lennart (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
-
- Lannfelt, L (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
-
Buerger, K (författare)
-
Moller, HJ (författare)
-
Hampel, H (författare)
-
Davidsson, P (författare)
-
Blennow, K (författare)
-
visa färre...
-
(creator_code:org_t)
- 2003
- 2003
- Engelska.
-
Ingår i: Experimental Neurology. - 0014-4886. ; 183, s. 74-
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) and Abeta. We examined the cerebrospinal fluid (CSF) for alpha- and beta-secretase cleaved sAPP (alpha-sAPP and beta-sAPP) in 81 sporadic AD patients, 19 patients with mild cognitive impairment, and 42 healthy controls by using newly developed sandwich enzyme-linked immunosorbent assay methods. We found that neither the level of CSF-alpha-sAPP nor CSF-beta-sAPP differed between sporadic AD patients and healthy controls. These findings further support the conclusion that there is no change in APP expression in sporadic AD. However, the level of CSF-beta-sAPP was significantly increased in patients with mild cognitive impairment compared to controls. We also investigated the relationship between the CSF level of alphabeta-sAPP and Abeta(42) and the apoE epsilon4 (apoFA.) allele. Significantly lower levels of CSF-alpha-sAPP were found in AD patients possessing one or two apoE4 alleles than in those not possessing the apoE4 allele. Neither the levels of CSF-beta-sAPP nor CSF-Abeta(42) differed when comparing ApoE4 allele-positive with allele-negative individuals. (C) 2003 Elsevier Science (USA). All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- cerebrospinal fluid
- beta-amyloid
- apolipoprotein E
- Alzheimer's disease
- amyloid precursor protein
- ELISA
- mild cognitive impairment
- secretase
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Olsson, A
-
Hoglund, K
-
Sjogren, M
-
Andreasen, N
-
Minthon, Lennart
-
Lannfelt, L
-
visa fler...
-
Buerger, K
-
Moller, HJ
-
Hampel, H
-
Davidsson, P
-
Blennow, K
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Experimental Neu ...
- Exp Neurol
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet
-
Uppsala universitet