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5-HT2AR and NMDAR p...
5-HT2AR and NMDAR psychedelics induce similar hyper-synchronous states in the rat cognitive-limbic cortex-basal ganglia system
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- Brys, Ivani (författare)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Integrative Neurophysiology,Lund University Research Groups,The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden; Research Group in Neuroscience and Experimental Psychology, Federal University of Vale do São Francisco, Petrolina, Brazil,Institutionen för integrativ medicinsk biologi (IMB)
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- Barrientos, Sebastian A (författare)
- Umeå universitet,Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Integrative Neurophysiology,Lund University Research Groups,Institutionen för integrativ medicinsk biologi (IMB),The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Ward, Jon Ezra (författare)
- The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Wallander, Jonathan (författare)
- The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Petersson, Per (författare)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LU profilområde: Naturlig och artificiell kognition,Lunds universitets profilområden,Integrative Neurophysiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LU Profile Area: Natural and Artificial Cognition,Lund University Profile areas,Institutionen för integrativ medicinsk biologi (IMB),The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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- Halje, Pär (författare)
- Lund University,Lunds universitet,Integrativ neurofysiologi,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),LU profilområde: Naturlig och artificiell kognition,Lunds universitets profilområden,Integrative Neurophysiology,Lund University Research Groups,LU Profile Area: Natural and Artificial Cognition,Lund University Profile areas,The Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Communications Biology. - : Springer Nature. - 2399-3642. ; 6:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The profound changes in perception and cognition induced by psychedelic drugs are thought to act on several levels, including increased glutamatergic activity, altered functional connectivity and an aberrant increase in high-frequency oscillations. To bridge these different levels of observation, we have here performed large-scale multi-structure recordings in freely behaving rats treated with 5-HT2AR psychedelics (LSD, DOI) and NMDAR psychedelics (ketamine, PCP). While interneurons and principal cells showed disparate firing rate modulations for the two classes of psychedelics, the local field potentials revealed a shared pattern of synchronized high-frequency oscillations in the ventral striatum and several cortical areas. Remarkably, the phase differences between structures were close to zero, corresponding to <1 ms delays. Likely, this hypersynchrony has major effects on the integration of information across neuronal systems and we propose that it is a key contributor to changes in perception and cognition during psychedelic drug use. Potentially, similar mechanisms could induce hallucinations and delusions in psychotic disorders and would constitute promising targets for new antipsychotic treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (ämneskategori)
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