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Aberrant nigral dif...
Aberrant nigral diffusion in Parkinson's disease : A longitudinal diffusion tensor imaging study
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- Loane, Clare (författare)
- Imperial College London
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- Politis, Marios (författare)
- Imperial College London
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- Kefalopoulou, Zinovia (författare)
- National Hospital for Neurology and Neurosurgery
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- Valle-Guzman, Natalie (författare)
- University of Cambridge
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- Paul, Gesine (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Translationell Neurologi,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Translational Neurology (TNY),Lund University Research Groups
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- Widner, Håkan (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Regeneration in Movement Disorders,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Foltynie, Thomas (författare)
- National Hospital for Neurology and Neurosurgery
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- Barker, Roger A (författare)
- University of Cambridge
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- Piccini, Paola (författare)
- Imperial College London
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(creator_code:org_t)
- 2016-04-22
- 2016
- Engelska.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185. ; 31:7, s. 6-1020
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous studies have reported a specific decrease of nigral fractional anisotropy in PD. However, to date the effect of disease progression on nigral or striatal diffusion indices has not been fully explored.METHODS: We have conducted a cross-sectional and longitudinal diffusion tensor imaging study in 18 early stage, treated PD patients and 14 age-matched controls. PD patients were scanned on 2 occasions OFF medication, 19.3 months apart (standard deviation = 3.1 months). Longitudinal change of regional nigral and striatal measures of fractional anisotropy and mean diffusivity were calculated using a region-of-interest approach.RESULTS: Region-of-interest analysis demonstrated that at baseline, PD patients and controls did not differ in regard to diffusion indices in any region assessed. A significant difference of nigral fractional anisotropy and mean diffusivity between controls and PD patients at follow-up was detected and confirmed with longitudinal analysis within PD patients. Alterations in striatal regions were not detected in either group or over time.CONCLUSION: Our findings indicate that nigral diffusion measure may be a valuable measure of disease progression. In the future, larger longitudinal studies will confirm whether diffusion indices may serve as sensitive and clinically meaningful measures of disease progression in PD. © 2016 International Parkinson and Movement Disorder Society.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Journal Article
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- art (ämneskategori)
- ref (ämneskategori)
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