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Benchmark dose for ...
Benchmark dose for cadmium-induced osteoporosis in women
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- Suwazono, Yasushi (författare)
- Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Chiba Univ, Grad Sch Med, Dept Occupat & Environm Med, Chiba, Japan.
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- Sand, Salomon (författare)
- Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.
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- Vahter, Marie (författare)
- Karolinska Institutet
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- Skerfving, Staffan (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Dept Occupat & Environm Med, Lund, Sweden.
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- Lidfeldt, Jonas (författare)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Malmö Univ Hosp, Dept Community Hlth, Malmö, Sweden.
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- Akesson, Agneta (författare)
- Karolinska Institutet
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Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden;Chiba Univ, Grad Sch Med, Dept Occupat & Environm Med, Chiba, Japan. Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden. (creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Toxicology Letters. - : Elsevier BV. - 1879-3169 .- 0378-4274. ; 197:2, s. 123-127
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We applied a hybrid approach to estimate the benchmark dose (BMD) and the lower 95% confidence limit (BMDL) for cadmium-induced bone effects in a population with low environmental exposure. Morning urine samples were collected by 794 Swedish women, aged 53-64 years, participating in a population-based study We measured urinary cadmium (U-Cd), a marker of long-term exposure, and bone mineral density, expressed as its T-score (reference 20-year old women) of the non-dominant wrist. BMD and BMDL, adjusted for relevant covariates. corresponding to an additional risk (BMR) of 5% or 10% were calculated, with the background risk at zero exposure set at 1% or 5%. With a BMR of 5% and a background risk of having low bone mineral density (at U-Cd=0) of 1% or 5% (corresponding to T-score cut-offs -2.75 and -2 09, respectively), the BMD of U-Cd ranged 1 8-3.7 mu g/g creatinine, and the BMDL ranged 1.0-2 1 mu g/g creatinine For a 5% BMR of osteoporosis (T-score < -2 5), the BMD was 29 mu g/g creatinine and the BMDL 1 6 mu g/g creatinine. The lowest obtained BMD of U-Cd for wrist bone mineral density was only slightly higher than the lowest reference concentration previously reported for cadmium-related kidney effects Our results provide additional scientific support for the low tolerably weekly intake (TWI) of cadmium set by the European Food Safety Authority in 2009. (C) 2010 Elsevier Ireland Ltd. All rights reserved
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Osteoporosis
- effect
- Bone
- Human
- Environmental exposure
- Benchmark dose
- Continuous data
- Risk assessment
- Urinary cadmium
- Benchmark dose
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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