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Biochemical markers...
Biochemical markers of bone metabolism after short and long time ethanol withdrawal in alcoholics
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- Nyquist, Fredrik (författare)
- Lund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Joint and Soft Tissue Unit,Lund University Research Groups
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Ljunghall, S (författare)
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- Berglund, Mats (författare)
- Lund University,Lunds universitet,Kliniskt Centrum för Hälsofrämjande Vård,Forskargrupper vid Lunds universitet,Clinical Health Promotion Centre,Lund University Research Groups
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- Obrant, Karl (författare)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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(creator_code:org_t)
- 1996
- 1996
- Engelska.
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Ingår i: Bone. - 1873-2763. ; 19:1, s. 51-54
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The etiology of ethanol-associated osteopenia is not fully understood. A direct inhibitory effect of ethanol on osteoblast function has been suggested by in vitro and in vivo studies. In this study, we measured biochemical markers for bone formation (osteocalcin, bone specific alkaline phosphatase, procollagen-1-c-terminal peptide) and resorption (c-terminal telopeptide and urine deoxypyridinoline) in 18 otherwise healthy, but severely alcoholic men during a 10-day period of alcohol withdrawal. The same tests were performed in a group of 18 male abstainers, with more than 5 years of proven alcohol withdrawal. The results were compared with 29 male controls, randomly selected. In the group of alcoholics, osteocalcin (Oc) was significantly decreased at day 1 (p > 0.001; compared with controls). The low serum Oc levels normalized during the observation period and no significant difference was seen after 10 days. After a 5-year withdrawal, the bone-specific alkaline phosphatase was increased (p = 0.040) and there was a tendency, but not significant, of a persistent high level of Oc when compared with controls. A significant increase in fasting urinary secretion of deoxypyrodinoline was seen among the alcoholics (p = 0.001 compared with controls). The increase did not normalize during the 10-day observation period. Also, the abstainers had a significantly higher fasting urinary secretion of deoxypyridinoline after a 5-year alcohol withdrawal (p = 0.022 compared with controls). The present study suggests that there is an imbalance between bone formation and bone resorption among alcoholics that could result in rapid bone loss. Although most directions tended to normalize shortly after alcohol withdrawal, biochemical data suggest that there may still be a persistent high bone turnover after more than 5 years.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Bone metabolism
- Ethanol
- Withdrawal
- Alcoholic
- Abstainers
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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